Cancer is one of the leading causes of mortality worldwide. The etiology of cancer has not
been fully elucidated yet, and further enhancements are necessary to optimize therapeutic …

Abstract Phosphoinositide-3 kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR)
signaling pathway is one of the most important proliferative signaling pathways with critical …

Osteosarcoma (OS) is the most common nonhematologic bone malignancy in children and
adolescents. Despite the advances of adjuvant chemotherapy and significant improvement …

Increased risk of colorectal cancer (CRC) is associated with altered intestinal microbiota as
well as short‐chain fatty acids (SCFAs) reduction of output The energy source of colon cells …

Cancer is a multi-step process that can be viewed as a cellular and immunological shift
away from homeostasis in response to selected infectious agents, mutations, diet, and …

Osteosarcoma (OS) is the most common type of primary malignant bone tumor and mainly
occurs in children and adolescent. Because of its early migration and invasion, OS has a …

Lymphoma is a heterogeneous group of diseases that often require their metabolism
program to fulfill the demand of cell proliferation. Features of metabolism in lymphoma cells …

Tumorigenesis is a multistep process, de-regulated due to the imbalance of oncogenes as
well as anti-oncogenes, resulting in disruption of tissue homeostasis. In many cases the …

Posttranslational modifications of histone proteins represent a fundamental means to define
distinctive epigenetic states and regulate gene expression during development and …

Though outcomes for pediatric Burkitt lymphoma (BL) have improved significantly in recent
decades with intensive multi-agent chemotherapy and the addition of rituximab …