Compared to normal cells, cancer cells strongly upregulate glucose uptake and glycolysis to
give rise to increased yield of intermediate glycolytic metabolites and the end product …

A potentially important aspect in the regulation of tumour metastasis is endocytosis. This
process consists of internalisation of cell-surface receptors via pinocytosis, phagocytosis or …

Thyroid carcinoma (TC) is the most common malignancy of endocrine organs. The cell
subpopulation in the lineage hierarchy that serves as cell of origin for the different TC …

[Frontiers in Bioscience E4, 1528-1541, January 1, 2012] 1528 The role of cancer stem cells in
relapse of solid tumors Yang Yu1 Page 1 [Frontiers in Bioscience E4, 1528-1541, January 1 …

Present therapeutic approaches do not effectively target metastatic cancers, often limited by
their inability to eliminate already-seeded non-proliferative, growth-arrested, or therapy …

The molecular mechanisms and genetic programs required for cancer metastasis are
sometimes overlapping, but components are clearly distinct from those promoting growth of …

Endocytosis in mammalian cells is a fundamental cellular machinery that regulates vital
physiological processes, such as the absorption of metabolites, release of neurotransmitters …

Background Triple-negative breast cancer (TNBC) constitutes 10–20% of breast cancers
and is challenging to treat due to a lack of effective targeted therapies. Previous studies in …

Cancer cells tend to utilize aerobic glycolysis even under normoxic conditions, commonly
called the “Warburg effect.” Aerobic glycolysis often directly correlates with malignancy, but …

Cancer disease is the second leading cause of death in the world and one of the main fields
of medical research. Although there is now a greater understanding of biological …