The widespread nature of several viruses is greatly credited to their rapidly altering RNA
genomes that enable the infection to persist despite challenges presented by host cells …

COVID-19, the highly contagious novel disease caused by SARS-CoV-2, has become a
major international concern as it has spread quickly all over the globe. However, scientific …

Background Dengue is a major mosquito-borne disease currently with no effective antiviral
or vaccine available. Effort to find antivirals for it has focused on bioflavonoids, a plant …

Dengue is the most prevalent arthropod-borne viral disease worldwide and affects
approximately 2.5 billion people living in over 100 countries. Increasing geographic …

Dengue is a significant global health problem. Even though a vaccine against dengue is
now available, which is a notable achievement, its long-term protective efficacy against each …

Highlights•Evaluating drug efficacy, specificity and toxicity may help to develop an optimal
treatment regime for in vivo studies.•Measuring time to resolve viremia in vivo may help to …

Dengue is a major global health threat causing 390 million dengue infections and 25,000
deaths annually. The lack of efficacy of the licensed Dengvaxia vaccine and the absence of …

The development of animal models of dengue virus (DENV) infection and disease has been
challenging, as epidemic DENV does not naturally infect non-human species. Non-human …

Emergence of Dengue as one of the deadliest viral diseases prompts the need for
development of effective therapeutic agents. Dengue virus (DV) exists in four different …

The dengue virus and related flaviviruses are an increasing global health threat. In this
perspective, we comment on and review medicinal chemistry efforts aimed at the prevention …