Abstract Interleukin-17A (IL-17A), the hallmark cytokine of the newly defined T helper 17
(TH17) cell subset, has important roles in protecting the host against extracellular …

Summary The interleukin‐17 (IL‐17) cytokines, IL‐17A to IL‐17F, are emerging as critical
players in host defence responses and inflammatory diseases. Substantial data support the …

IL-17 is an inflammatory cytokine produced primarily by a unique lineage of CD4 T cells that
plays critical roles in the pathogenesis of multiple autoimmune diseases. IL-17RA is a …

Abstract Interleukin 17C (IL-17C) is a member of the IL-17 family that is selectively induced
in epithelia by bacterial challenge and inflammatory stimuli. Here we show that IL-17C …

Abstract Interleukin 17 receptor E (IL-17RE) is an orphan receptor of the IL-17 receptor
family. Here we show that IL-17RE is a receptor specific to IL-17C and has an essential role …

Summary Although several interleukin-17 (IL-17) family members and their receptors have
been recently appreciated as important regulators in inflammatory diseases, the function of …

Abstract Interleukin 17 (IL-17)-producing helper T cells (TH-17 cells), together with their
effector cytokines, including members of the IL-17 family, are emerging as key mediators of …

Th17 cells are a subset of T helper cells that have been recently found to play important
functions in host defense and the pathogenesis of various human autoimmune and …

Therapeutic targeting of IL-17A and its receptor IL-17RA with antibodies has turned out to be
a tremendous success in the treatment of several autoimmune conditions. As the IL-17 …

Introduction Accumulating evidence suggests that the interleukin (IL)-17 cytokines are major
players in the immune response to foreign pathogens. In addition, the pathogeneses of a …