Lipid droplets (LDs) provide a reservoir for triacylglycerol storage and are a central hub for
fatty acid trafficking and signaling in cells. Lipolysis promotes mitochondrial biogenesis and …

Abiotic stresses have significant impacts on crop yield and quality. Even though significant
efforts during the past decade have been devoted to uncovering the core signaling …

The TAM family of receptor tyrosine kinases is implicated in multiple distinct oncogenic
signaling pathways. However, to date, there are no FDA-approved small molecule inhibitors …

The DNAJB1–PRKACA fusion is the signature genetic event of fibrolamellar hepatocellular
carcinoma (FL-HCC), a rare but lethal liver cancer that primarily affects adolescents and …

The pathogenic role of the overactivated ABL1 tyrosine kinase (TK) pathway is well
recognized in some forms of BCR-ABL1 like acute lymphoblastic leukemia (ALL); TK …

FMS-like tyrosine kinase 3 (FLT3) is mutated in∼ 30% of patients that suffer from acute
myeloid leukemia (AML). In about 25% of all AML patients, in-frame insertions are observed …

Bruton's tyrosine kinase (BTK) is a well-documented target for cancer therapeutics due to its
role in B-cell signaling pathways. However, inhibitor design is hindered by lack of tools to …

FMS-like tyrosine kinase 3 (Flt3) is an oncogenic kinase implicated in leukemia, with its
primary association being acute myeloid leukemia (AML). Flt3-specific inhibitors have …

Posttranslational modification (PTM) enzymes are important modulators of protein structure
and function. They typically act by chemically modifying amino acids, often on side chain …

Novel time-resolved terbium luminescence assays were developed for CDK5 and CDK2 by
designing synthetic substrates which incorporate phospho-inducible terbium sensitizing …