Photodynamic therapy for hypoxic tumors: Advances and perspectives

L Huang, S Zhao, J Wu, L Yu, N Singh, K Yang… - Coordination Chemistry …, 2021 - Elsevier
Photodynamic therapy (PDT) has been a preferred clinical technology for treating superficial
tumors due to its advantages of high selectivity, non-invasiveness and negligible drug …

Singlet molecular oxygen reactions with nucleic acids, lipids, and proteins

P Di Mascio, GR Martinez, S Miyamoto… - Chemical …, 2019 - ACS Publications
Singlet oxygen (1O2) is a biologically relevant reactive oxygen species capable of efficiently
reacting with cellular constituents. The resulting oxidatively generated damage to nucleic …

Trends and targets in antiviral phototherapy

A Wiehe, JM O'Brien, MO Senge - Photochemical & Photobiological …, 2019 - pubs.rsc.org
Photodynamic therapy (PDT) is a well-established treatment option in the treatment of
certain cancerous and pre-cancerous lesions. Though best-known for its application in …

The good, the bad, and the ugly–controlling singlet oxygen through design of photosensitizers and delivery systems for photodynamic therapy

S Callaghan, MO Senge - Photochemical & photobiological sciences, 2018 - pubs.rsc.org
Singlet oxygen, although integral to photodynamic therapy, is notoriously uncontrollable,
suffers from poor selectivity and has fast decomposition rates in biological media. Across the …

Targeted singlet oxygen delivery: a bioorthogonal metabolic shunt linking hypoxia to fast singlet oxygen release

H Wu, L Wang, Y Wang, Y Shao, G Li… - Angewandte Chemie …, 2022 - Wiley Online Library
Singlet oxygen can be generated by thermal cycloreversion of aromatic endoperoxides.
However, for any practical potential of chemically generated singlet oxygen within a …

Visible‐Light‐Mediated Synthesis of β‐Chloro Ketones from Aryl Cyclopropanes

D Petzold, P Singh, F Almqvist… - Angewandte Chemie …, 2019 - Wiley Online Library
We report the visible‐light‐mediated synthesis of β‐chloro ketones from aryl cyclopropanes,
oxygen, hydrochloric acid, and nitric acid. The operationally simple and catalyst‐free method …

A singlet oxygen reservoir based on poly-pyridone and porphyrin nanoscale metal–organic framework for cancer therapy

BR Xie, CX Li, Y Yu, JY Zeng, MK Zhang… - CCS …, 2021 - chinesechemsoc.org
Here, a methacrylate-modified pyridone derivative (mPYR) was loaded into a porphyrin
nanoscale metal–organic framework (porphyrin-nMOF). Then, the loaded mPYR was further …

Porphyrin–ferrocene conjugates for photodynamic and chemodynamic therapy

Z Lei, X Zhang, X Zheng, S Liu, Z Xie - Organic & biomolecular …, 2018 - pubs.rsc.org
Chemodynamic therapy can convert endogenous hydrogen peroxide (H2O2) at tumor
localization into the toxic hydroxyl radical (˙ OH) destroying tumor cells. Photodynamic …

Constructing Singlet Oxygen “Slow Release” Platform to Optimize the Performance of Commercial Photosensitizers

Y Ni, J Wang, W Ai, Z Yu, X Zhu, S Wang… - Advanced Optical …, 2024 - Wiley Online Library
Commercial photosensitizers (PSs) present great potential in the field of clinical
photodynamic therapy (PDT) yet face a formidable challenge owing to the extremely short …

Pillar [5] arene based supramolecular polymer for a singlet oxygen reservoir

B Lu, J Wang, Z Zhang, X Yan, Q Zhao, Y Ding… - Polymer …, 2022 - pubs.rsc.org
A new diphenylanthracene derivative (bis (5-cyanopentyl) 4, 4′-(anthracene-9, 10-diyl)
dibenzoate) has been designed and synthesized, which can form a host–guest complex with …