Tumor suppressor genes cooperate with each other in tumors. Three important tumor
suppressor proteins, retinoblastoma (Rb), p53, phosphatase, and tensin homolog deleted …

The immune system is under control of the circadian clock. Many of the circadian rhythms
observed in the immune system originate in direct interactions between components of the …

Period determination in the mammalian circadian clock involves the turnover rate of the
repressors CRY and PER. We show that CRY ubiquitination engages two competing E3 …

The expression of 'clock'genes occurs in all tissues, but especially in the suprachiasmatic
nuclei (SCN) of the hypothalamus, groups of neurons in the brain that regulate circadian …

Various features, components, and functions of the immune system present daily variations.
Immunocompetent cell counts and cytokine levels present variations according to the time of …

Endogenous biological rhythms with approximately 24-h periodicity are generated by the
circadian clock, in which clock genes coordinate with one another and form a transcriptional …

Most aspects of mammalian function display circadian rhythms driven by an endogenous
clock. The circadian clock is operated by genes and comprises a central clock in the brain …

The basic helix-loop-helix-PAS transcription factor (CLOCK, Circadian locomotor output
cycles protein kaput) was discovered in 1994 as a circadian clock. Soon after its discovery …

Deubiquitinases are important components of the protein degradation regulatory network.
We report the discovery of ML364, a small molecule inhibitor of the deubiquitinase USP2 …

Humans as diurnal beings are active during the day and rest at night. This daily oscillation of
behavior and physiology is driven by an endogenous circadian clock not environmental …