The quality of diffraction data obtained using silver and molybdenum microsources has been
compared for six model compounds with a wide range of absorption factors. The …

Serial crystallography, using either femtosecond X-ray pulses from free-electron laser
sources or short synchrotron-radiation exposures, has the potential to reveal metalloprotein …

Introduction: X-ray crystallography plays an important role in structure-based drug design
(SBDD), and accurate analysis of crystal structures of target macromolecules and …

A new approach that integrates data collection, data reduction, phasing and model building
significantly accelerates the process of structure determination and on average minimizes …

ATP binding cassette (ABC) transporters play critical roles in maintaining sterol balance in
higher eukaryotes. The ABCG5/ABCG8 heterodimer (G5G8) mediates excretion of neutral …

Approximately 10% of human protein kinases are believed to be inactive and named
pseudokinases because they lack residues required for catalysis. Here, we show that the …

Enzymes with a protein kinase fold transfer phosphate from adenosine 5′-triphosphate
(ATP) to substrates in a process known as phosphorylation. Here, we show that the …

Sphingomyelin and cholesterol are essential lipids that are enriched in plasma membranes
of animal cells, where they interact to regulate membrane properties and many intracellular …

The antibiotic trimethoprim (TMP) is used to treat a variety of Escherichia coli infections, but
its efficacy is limited by the rapid emergence of TMP-resistant bacteria. Previous laboratory …

During viral RNA synthesis, Ebola virus (EBOV) nucleoprotein (NP) alternates between an
RNA-template-bound form and a template-free form to provide the viral polymerase access …