Amyotrophic lateral sclerosis (ALS) is a relentlessly progressive and fatal
neurodegenerative disorder that primarily affects motor neurons. Despite our increased …

Irisin, the circulating peptide originating from fibronectin type III domain-containing protein 5
(FNDC5), is mainly expressed by muscle fibers under peroxisome proliferator-activated …

Peroxisome proliferator-activated receptor gamma coactivator-1 (PGC-1) family (PGC-1s),
consisting of three members encompassing PGC-1α, PGC-1β, and PGC-1-related …

Oxidative stress has been implicated in the etiology and pathobiology of various
neurodegenerative diseases. At baseline, the cells of the nervous system have the capability …

Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease
characterized by the progressive loss of motor neurons, for which current treatment options …

Parkinson's disease (PD) is considered one of the most common neurodegenerative brain
diseases which involves the deposition of α-synuclein. Irisin hormone, a newly discovered …

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease that produces a
selective loss of the motor neurons of the spinal cord, brain stem and motor cortex. Oxidative …

Mitochondria are essential organelles for neuronal function and cell survival. Besides the
well-known bioenergetics, additional mitochondrial roles in calcium signaling, lipid …

The onset and mechanisms underlying neurodegenerative diseases remain uncertain. The
main features of neurodegenerative diseases have been related with cellular and molecular …

Peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC-1 alpha) is a
protein that regulates metabolism and inflammation by activating nuclear receptors …