[HTML][HTML] Battles against aberrant KEAP1-NRF2 signaling in lung cancer: intertwined metabolic and immune networks
The Kelch-like ECH-associated protein 1/nuclear factor erythroid-derived 2-like 2
(KEAP1/NRF2) pathway is well recognized as a key regulator of redox homeostasis …
(KEAP1/NRF2) pathway is well recognized as a key regulator of redox homeostasis …
The multifaceted roles of NRF2 in Cancer: friend or foe?
C Glorieux, C Enríquez, C González… - Antioxidants, 2024 - mdpi.com
Physiological concentrations of reactive oxygen species (ROS) play vital roles in various
normal cellular processes, whereas excessive ROS generation is central to disease …
normal cellular processes, whereas excessive ROS generation is central to disease …
Synergistic effect of PS-MPs and Cd on male reproductive toxicity: Ferroptosis via Keap1-Nrf2 pathway
It has been wildly reported that microplastics (MPs) can adsorb heavy metals and act as
carriers for their transport into organisms. However, the combined toxicity of MPs and heavy …
carriers for their transport into organisms. However, the combined toxicity of MPs and heavy …
Wdr1 and cofilin are necessary mediators of immune-cell-specific apoptosis triggered by Tecfidera
Despite the emerging importance of reactive electrophilic drugs, deconvolution of their
principal targets remains difficult. The lack of genetic tractability/interventions and reliance …
principal targets remains difficult. The lack of genetic tractability/interventions and reliance …
[HTML][HTML] Brief homogeneous TCR signals instruct common iNKT progenitors whose effector diversification is characterized by subsequent cytokine signaling
S Bortoluzzi, N Dashtsoodol, T Engleitner, C Drees… - Immunity, 2021 - cell.com
Innate-like T cell populations expressing conserved TCRs play critical roles in immunity
through diverse developmentally acquired effector functions. Focusing on the prototypical …
through diverse developmentally acquired effector functions. Focusing on the prototypical …
ROS fine-tunes the function and fate of immune cells
S Liu, B Huang, J Cao, Y Wang, H Xiao, Y Zhu… - International …, 2023 - Elsevier
The redox state is essential to the process of cell life, which determines cell fate. As an
important signaling molecule of the redox state, reactive oxygen species (ROS) are crucial …
important signaling molecule of the redox state, reactive oxygen species (ROS) are crucial …
The redox sensor KEAP1 facilitates adaptation of T cells to chronic antigen stimulation by preventing hyperactivation
During persistent antigen stimulation, exhausted CD8+ T cells are continuously replenished
by self-renewing stem-like T cells. However, how CD8+ T cells adapt to chronic stimulation …
by self-renewing stem-like T cells. However, how CD8+ T cells adapt to chronic stimulation …
Nutraceuticals as potential therapeutic modulators in immunometabolism
G Alba, H Dakhaoui, C Santa-Maria, F Palomares… - Nutrients, 2023 - mdpi.com
Nutraceuticals act as cellular and functional modulators, contributing to the homeostasis of
physiological processes. In an inflammatory microenvironment, these functional foods can …
physiological processes. In an inflammatory microenvironment, these functional foods can …
METTL14-dependent m6A modification controls iNKT cell development and function
Summary N 6-methyladenosine (m 6 A), the most common form of RNA modification,
controls CD4+ T cell homeostasis by targeting the IL-7/STAT5/SOCS signaling pathways …
controls CD4+ T cell homeostasis by targeting the IL-7/STAT5/SOCS signaling pathways …
Orchestrated action of AMPK activation and combined VEGF/PD-1 blockade with lipid metabolic tunning as multi-target therapeutics against ovarian cancers
Ovarian cancer is one of the most lethal gynecological malignancies worldwide, and
chemoresistance is a critical obstacle in the clinical management of the disease. Recent …
chemoresistance is a critical obstacle in the clinical management of the disease. Recent …