The role of natural products in drug discovery and development against neglected tropical diseases

PM Cheuka, G Mayoka, P Mutai, K Chibale - Molecules, 2016 - mdpi.com
Endemic in 149 tropical and subtropical countries, neglected tropical diseases (NTDs) affect
more than 1 billion people annually, including 875 million children in developing …

Constituents from Salvia Species and Their Biological Activities

YB Wu, ZY Ni, QW Shi, M Dong, H Kiyota… - Chemical …, 2012 - ACS Publications
The Lamiaceae (formerly Labiatae), a widespread family, comprises 220 genera and 4000
species distributed throughout most of the world as annuals and perennial plants. The …

Antimicrobial activity of oleanolic and ursolic acids: an update

JA Jesus, JHG Lago, MD Laurenti… - Evidence‐Based …, 2015 - Wiley Online Library
Triterpenoids are the most representative group of phytochemicals, as they comprise more
than 20,000 recognized molecules. These compounds are biosynthesized in plants via …

Natural product based leads to fight against leishmaniasis

N Singh, BB Mishra, S Bajpai, RK Singh… - Bioorganic & medicinal …, 2014 - Elsevier
The growing incidence of parasitic resistance against generic pentavalent antimonials,
specifically for visceral disease in Indian subcontinent, is a serious issue in Leishmania …

Searching for drugs for Chagas disease, leishmaniasis and schistosomiasis: a review

SS Santos, RV de Araújo, J Giarolla, O El Seoud… - International journal of …, 2020 - Elsevier
Chagas disease, leishmaniasis and schistosomiasis are neglected diseases (NDs) and are
a considerable global challenge. Despite the huge number of people infected, NDs do not …

Determination of antioxidant, DNA protection, enzyme inhibition potential and molecular docking studies of a biomarker ursolic acid in Nepeta species

S Yenigün, Y Başar, Y İpek, L Behçet… - Journal of …, 2024 - Taylor & Francis
Ursolic acid (UA), which has many biological properties such as anti-cancer, anti-
inflammatory and antioxidant, and regulates some pharmacological processes, has been …

Bioactive Triterpenoids from Salvia Species

G Topçu - Journal of natural products, 2006 - ACS Publications
Salvia species are important medicinal and culinary plants, and they have been the subject
of numerous chemical and biological studies. The bioactive triterpenoids of Salvia species …

[HTML][HTML] Chemical composition and antiprotozoal activities of Colombian Lippia spp essential oils and their major components

P Escobar, S Milena Leal, LV Herrera… - Memórias do Instituto …, 2010 - SciELO Brasil
The chemical composition and biological activities of 19 essential oils and seven of their
major components were tested against free and intracellular forms of Leishmania chagasi …

NpPDR1, a Pleiotropic Drug Resistance-Type ATP-Binding Cassette Transporter from Nicotiana plumbaginifolia, Plays a Major Role in Plant Pathogen Defense

Y Stukkens, A Bultreys, S Grec, T Trombik… - Plant …, 2005 - academic.oup.com
Nicotiana plumbaginifolia NpPDR1, a plasma membrane pleiotropic drug resistance-type
ATP-binding cassette transporter formerly named NpABC1, has been suggested to transport …

Bioactive phytochemicals from shoots and roots of Salvia species

AR Jassbi, S Zare, O Firuzi, J Xiao - Phytochemistry reviews, 2016 - Springer
The plants of the genus Salvia L. are important medicinal herbs of the Lamiaceae family and
some of them such as S. officinalis (sage), S. miltiorrhiza (red sage, Danshen) and S. sclarea …