Although musculoskeletal diseases such as osteoporosis are diagnosed and treatment
outcome is evaluated based mainly on routine clinical outcomes of bone mineral density …

Tissue-level mechanical properties characterize mechanical behavior independently of
microscopic porosity. Specifically, quasi-static nanoindentation provides measurements of …

Osteogenesis imperfecta is an inherited connective tissue disorder with wide phenotypic
and molecular heterogen-eity. A common issue associated with the molecular ab-normality …

The last few decades have been marked by the identification of numerous genes implicated
in genetic disorders, helping in the elucidation of the underlying pathophysiology of these …

Osteogenesis imperfecta type III (OI) is a serious genetic condition with poor bone quality
and a high fracture rate in children. In a previous study, it was shown that a monoclonal …

(1) Background: Osteogenesis imperfecta (OI) is a rare skeletal dysplasia characterized as a
heterogeneous disorder group with well-defined phenotypic and genetic features that share …

Craniofacial and dentoalveolar abnormalities are present in all types of osteogenesis
imperfecta (OI). Mouse models of the disorder are critical to understand these abnormalities …

Osteogenesis imperfecta (OI) is a rare congenital bone dysplasia characterized by high
fracture rates and broad variations in clinical manifestations ranging from mild to …

Background Cancer patients receiving radiotherapy for soft tissue sarcomas are often at risk
of post-irradiation (post-RTx) bone fragility fractures, but our understanding of factors …

Abstract Sclerostin antibody (Scl-Ab) restored bone mass and strength in the ovariectomized
rat model of postmenopausal osteoporosis. Increased bone mineral density (BMD) and …