Diabetes is a complex disease that affects over 400 million people worldwide. The life-long
insulin injections and continuous blood glucose monitoring required in type 1 diabetes …

The liver is the current site of choice for pancreatic islet transplantation, even though it is far
from being an ideal site because of immunologic, anatomic, and physiologic factors leading …

OBJECTIVE Curing type 1 diabetes by transplanting pancreatic islets into the liver is
associated with poor long-term outcome and graft failure at least partly due to inadequate …

Intraportal islet transplantation has a long history as a procedure for clinical islet
transplantation. However, many recent studies revealed that the intraportal procedure has …

Aims/hypothesis Beta cell replacement is a potential cure for type 1 diabetes. In humans,
islet transplants are currently infused into the liver via the portal vein, although this site has …

Although islet transplantation has demonstrated its potential use in treating type 1 diabetes,
this remains limited by the need for daily immunosuppression. Islet encapsulation was then …

Aims/Hypothesis Although the muscle is one of the preferable transplant sites in islet
transplantation, its transplant efficacy is poor. Here we attempted to determine whether an …

Pancreatic islet transplantation is presently almost exclusively performed using the
intraportal route for transplantation into the liver. However, islets at this site are poorly …

Islet cell transplantation has been limited most by poor graft survival. Optimizing the site of
transplantation could improve clinical outcomes by minimizing required donor cells …

Background The efficacy of intramuscular islet transplantation is poor despite being
technically simple, safe, and associated with reduced rates of severe complications. We …