Hypericum perforatum is a perennial plant, with worldwide distribution, commonly known as
St. John's wort. It has been used for centuries in traditional medicine for the treatment of …

ABSTRACT Introduction: Acetylcholinesterase (AChE) is the major enzyme that hydrolyzes
acetylcholine, a key neurotransmitter for synaptic transmission, into acetic acid and choline …

Acetylcholinesterase (AChE; EC 3.1. 1.7) plays a crucial role in the rapid hydrolysis of the
neurotransmitter acetylcholine, in the central and peripheral nervous system and might also …

Numerous studies suggest energy failure and accumulative intracellular waste play a causal
role in the pathogenesis of several neurodegenerative disorders and Alzheimer's disease …

Standardized extract from the leaves of the Ginkgo biloba tree, labeled EGb761, is one of
the most popular herbal supplements. Numerous preclinical studies have shown the …

Toxoplasmosis is a major public health concern due to neurotropic nature and role in the
development of mental and behavioral disorders. Alzheimer's disease (AD) is an important …

Crocin, as a carotenoid, is one of the main and active constituents of saffron stigmas (Crocus
sativus L.) that is widely used in folk medicine. Several studies have pointed out the potent …

Alzheimer's disease (AD) is a neurodegenerative disorder in which the amyloid-β (Aβ)
oligomers are a key factor in synaptic impairment and in spatial memory decline associated …

Diabetes mellitus is a very common chronic disease with progressively increasing
prevalence. Besides the well-known autoimmune and inflammatory pathogenesis of type 1 …

Soluble β-amyloid peptides (Aβ) and small Aβ oligomers represent the most toxic peptide
moieties recognized in brains affected by Alzheimer's disease (AD). Here we provide the first …