Addressing the benefits of inhibiting APOBEC3-dependent mutagenesis in cancer
Mutational signatures associated with apolipoprotein B mRNA-editing enzyme catalytic
polypeptide-like (APOBEC) 3 cytosine deaminase activity have been found in over half of …
polypeptide-like (APOBEC) 3 cytosine deaminase activity have been found in over half of …
APOBEC: A molecular driver in cervical cancer pathogenesis
S Revathidevi, AK Murugan, H Nakaoka, I Inoue… - Cancer letters, 2021 - Elsevier
Cervical cancer is one of the foremost common cancers in women. Human papillomavirus
(HPV) infection remains a major risk factor of cervical cancer. In addition, numerous other …
(HPV) infection remains a major risk factor of cervical cancer. In addition, numerous other …
Pan-cancer characterization of immune-related lncRNAs identifies potential oncogenic biomarkers
Y Li, T Jiang, W Zhou, J Li, X Li, Q Wang, X Jin… - Nature …, 2020 - nature.com
Long noncoding RNAs (lncRNAs) are emerging as critical regulators of gene expression
and they play fundamental roles in immune regulation. Here we introduce an integrated …
and they play fundamental roles in immune regulation. Here we introduce an integrated …
Induction of APOBEC3 exacerbates DNA replication stress and chromosomal instability in early breast and lung cancer evolution
S Venkatesan, M Angelova, C Puttick, H Zhai… - Cancer discovery, 2021 - AACR
APOBEC3 enzymes are cytosine deaminases implicated in cancer. Precisely when
APOBEC3 expression is induced during cancer development remains to be defined. Here …
APOBEC3 expression is induced during cancer development remains to be defined. Here …
Identification of new driver and passenger mutations within APOBEC-induced hotspot mutations in bladder cancer
Background APOBEC-driven mutagenesis and functional positive selection of mutated
genes may synergistically drive the higher frequency of some hotspot driver mutations …
genes may synergistically drive the higher frequency of some hotspot driver mutations …
Molecular origins of APOBEC-associated mutations in cancer
M Petljak, J Maciejowski - DNA repair, 2020 - Elsevier
The APOBEC family of cytidine deaminases has been proposed to represent a major
enzymatic source of mutations in cancer. Here, we summarize available evidence that links …
enzymatic source of mutations in cancer. Here, we summarize available evidence that links …
The cytidine deaminase APOBEC3G contributes to cancer mutagenesis and clonal evolution in bladder cancer
Mutagenic processes leave distinct signatures in cancer genomes. The mutational
signatures attributed to APOBEC3 cytidine deaminases are pervasive in human cancers …
signatures attributed to APOBEC3 cytidine deaminases are pervasive in human cancers …
Competition for DNA binding between the genome protector replication protein A and the genome modifying APOBEC3 single-stranded DNA deaminases
The human APOBEC family of eleven cytosine deaminases use RNA and single-stranded
DNA (ssDNA) as substrates to deaminate cytosine to uracil. This deamination event has …
DNA (ssDNA) as substrates to deaminate cytosine to uracil. This deamination event has …
Progesterone from ovulatory menstrual cycles is an important cause of breast cancer
HJT Coelingh Bennink, IJ Schultz, M Schmidt… - Breast cancer …, 2023 - Springer
Many factors, including reproductive hormones, have been linked to a woman's risk of
developing breast cancer (BC). We reviewed the literature regarding the relationship …
developing breast cancer (BC). We reviewed the literature regarding the relationship …
TargetGeneReg 2.0: a comprehensive web-atlas for p53, p63, and cell cycle-dependent gene regulation
M Fischer, R Schwarz, K Riege, JA DeCaprio… - NAR …, 2022 - academic.oup.com
In recent years, our web-atlas at www. TargetGeneReg. org has enabled many researchers
to uncover new biological insights and to identify novel regulatory mechanisms that affect …
to uncover new biological insights and to identify novel regulatory mechanisms that affect …