How ricin damages the ribosome
P Grela, M Szajwaj, P Horbowicz-Drożdżal… - Toxins, 2019 - mdpi.com
Ricin belongs to the group of ribosome-inactivating proteins (RIPs), ie, toxins that have
evolved to provide particular species with an advantage over other competitors in nature …
evolved to provide particular species with an advantage over other competitors in nature …
Sordarin— An anti‐fungal antibiotic with a unique modus operandi
Y Shao, E Molestak, W Su, M Stankevič… - British journal of …, 2022 - Wiley Online Library
Fungal infections cause serious problems in many aspects of human life, in particular
infections in immunocompromised patients present serious problems. Current anti‐fungal …
infections in immunocompromised patients present serious problems. Current anti‐fungal …
Structural basis for the interaction of Shiga toxin 2a with a C-terminal peptide of ribosomal P stalk proteins
The principal virulence factor of human pathogenic enterohemorrhagic Escherichia coli is
Shiga toxin (Stx). Shiga toxin 2a (Stx2a) is the subtype most commonly associated with …
Shiga toxin (Stx). Shiga toxin 2a (Stx2a) is the subtype most commonly associated with …
Multiplication of ribosomal P-stalk proteins contributes to the fidelity of translation
L Wawiórka, E Molestak, M Szajwaj… - … and Cellular Biology, 2017 - Am Soc Microbiol
The P-stalk represents a vital element within the ribosomal GTPase-associated center,
which represents a landing platform for translational GTPases. The eukaryotic P-stalk exists …
which represents a landing platform for translational GTPases. The eukaryotic P-stalk exists …
Arginine residues on the opposite side of the active site stimulate the catalysis of ribosome depurination by ricin A chain by interacting with the P-protein stalk
Ricin inhibits protein synthesis by depurinating the α-sarcin/ricin loop (SRL). Ricin holotoxin
does not inhibit translation unless the disulfide bond between the A (RTA) and B (RTB) …
does not inhibit translation unless the disulfide bond between the A (RTA) and B (RTB) …
Synthesis and structural characterization of ricin inhibitors targeting ribosome binding using fragment-based methods and structure-based design
XP Li, RK Harijan, B Cao, JN Kahn… - Journal of medicinal …, 2021 - ACS Publications
Ricin toxin A subunit (RTA) is the catalytic subunit of ricin, which depurinates an adenine
from the sarcin/ricin loop in eukaryotic ribosomes. There are no approved inhibitors against …
from the sarcin/ricin loop in eukaryotic ribosomes. There are no approved inhibitors against …
Human ribosomal P1-P2 heterodimer represents an optimal docking site for ricin A chain with a prominent role for P1 C-terminus
P Grela, XP Li, P Horbowicz, M Dźwierzyńska… - Scientific reports, 2017 - nature.com
The eukaryotic P-stalk contains two P1-P2 protein dimers with a conserved C-terminal
domain (CTD) critical for the interaction with external factors. To understand the role of the …
domain (CTD) critical for the interaction with external factors. To understand the role of the …
Do the A subunits contribute to the differences in the toxicity of Shiga toxin 1 and Shiga toxin 2?
Shiga toxin producing Escherichia coli O157: H7 (STEC) is one of the leading causes of
food-poisoning around the world. Some STEC strains produce Shiga toxin 1 (Stx1) and/or …
food-poisoning around the world. Some STEC strains produce Shiga toxin 1 (Stx1) and/or …
Shiga toxin 1 is more dependent on the P proteins of the ribosomal stalk for depurination activity than Shiga toxin 2
JC Chiou, XP Li, M Remacha, JPG Ballesta… - The international journal …, 2011 - Elsevier
Shiga toxins produced by Escherichia coli O157: H7 are responsible for food poisoning and
hemolytic uremic syndrome (HUS). The A subunits of Shiga toxins (Stx1A and Stx2A) inhibit …
hemolytic uremic syndrome (HUS). The A subunits of Shiga toxins (Stx1A and Stx2A) inhibit …