The emerging awareness of the contribution of epigenetic processes to genome function in
health and disease is underpinned by decades of research in model systems. In particular …

Parent-of-origin effects occur when the phenotypic effect of an allele depends on whether it
is inherited from the mother or the father. Several phenomena can cause parent-of-origin …

More than one-half billion people are obese, and despite progress in genetic research,
much of the heritability of obesity remains enigmatic. Here, we identify a Trim28-dependent …

Aging involves the deterioration of organismal function, leading to the emergence of multiple
pathologies. Environmental stimuli, including lifestyle, can influence the trajectory of this …

Background Changes in imprinted gene dosage in the placenta may compromise the
prenatal control of nutritional resources. Indeed monoallelic behaviour and sensitivity to …

Within the vertebrate groups, only mammals are subject to a specialized epigenetic process
termed genomic imprinting in which genes are preferentially expressed from one parental …

Genomic imprinting characterizes genes with a monoallelic expression, which is dependent
on the parental origin of each allele. Approximately 150 imprinted genes are known to date …

Genomic imprinting is a form of epigenetic inheritance whereby the regulation of a gene or
chromosomal region is dependent on the sex of the transmitting parent. During …

Genomic imprinting is manifested as differential allelic expression (DAE) depending on the
parent-of-origin. The most direct way to identify imprinted genes is to directly score the DAE …

Many questions about the regulation, functional specialization, computational prediction,
and evolution of genomic imprinting would be better addressed by having an exhaustive …