An essential step in renal function entails the formation of an ultrafiltrate that is delivered to
the renal tubules for subsequent processing. This process, known as glomerular filtration, is …

Genetic studies of hereditary forms of nephrotic syndrome have identified several proteins
that are involved in regulating the permselective properties of the glomerular filtration …

Albuminuria is a hallmark of glomerular disease of various etiologies. It is not only a
symptom of glomerular disease but also a cause leading to glomerulosclerosis, interstitial …

Renin-angiotensin system (RAS) plays a key role in the development and progression of
chronic kidney disease (CKD). Recent studies have demonstrated activation of Wnt/β …

Imaging is widely used in anticancer drug development, typically for whole-body tracking of
labelled drugs to different organs or to assess drug efficacy through volumetric …

Intravital microscopy (IVM) study approach offers several advantages over in vitro, ex vivo,
and 3D models. IVM provides real-time imaging of cellular events, which provides us a …

People of African ancestry carrying certain APOL1 mutant alleles are at elevated risk of
developing renal diseases. However, the mechanisms underlying APOL1-associated renal …

Abstract The (pro) renin receptor [(P) RR, Atp6ap2] was initially discovered as a membrane-
bound binding partner of prorenin and renin. A soluble (P) RR has additional paracrine …

Background The kidney is considered to be a structurally stable organ with limited baseline
cellular turnover. Nevertheless, single cells must be constantly replaced to conserve the …

Intravital microscopy (IVM) expands our understanding of cellular and molecular processes,
with applications ranging from fundamental biology to (patho) physiology and immunology …