Harmonizing the neurobiology and treatment of obsessive-compulsive disorder

WK Goodman, EA Storch… - American Journal of …, 2021 - Am Psychiatric Assoc
Obsessive-compulsive disorder (OCD) is a common, chronic, and oftentimes disabling
disorder. The only established first-line treatments for OCD are exposure and response …

Brain circuitry of compulsivity

OA Van den Heuvel, G van Wingen… - European …, 2016 - Elsevier
Compulsivity is associated with alterations in the structure and the function of parallel and
interacting brain circuits involved in emotional processing (involving both the reward and the …

Obsessive–compulsive disorder

DJ Stein, DLC Costa, C Lochner, EC Miguel… - Nature reviews Disease …, 2019 - nature.com
Obsessive–compulsive disorder (OCD) is a highly prevalent and chronic condition that is
associated with substantial global disability. OCD is the key example of the 'obsessive …

[PDF][PDF] Mapping compulsivity in the DSM-5 obsessive compulsive and related disorders: cognitive domains, neural circuitry, and treatment

NA Fineberg, AM Apergis-Schoute… - International Journal …, 2018 - academic.oup.com
Compulsions are repetitive, stereotyped thoughts and behaviors designed to reduce harm.
Growing evidence suggests that the neurocognitive mechanisms mediating behavioral …

Dorsal anterior cingulotomy and anterior capsulotomy for severe, refractory obsessive-compulsive disorder: a systematic review of observational studies

LT Brown, CB Mikell, BE Youngerman, Y Zhang… - Journal of …, 2016 - thejns.org
OBJECT The object of this study was to perform a systematic review, according to Preferred
Reporting Items of Systematic reviews and Meta-Analyses (PRISMA) and Agency for …

Neuroscientifically informed formulation and treatment planning for patients with obsessive-compulsive disorder: a review

DD Dougherty, BP Brennan, SE Stewart… - Jama …, 2018 - jamanetwork.com
Importance Obsessive-compulsive disorder (OCD) is a common and often debilitating
psychiatric illness. Recent advances in the understanding of the neuroscience of OCD have …

Magnetic resonance-guided focused ultrasound capsulotomy for refractory obsessive compulsive disorder and major depressive disorder: clinical and imaging results …

B Davidson, C Hamani, JS Rabin, M Goubran… - Molecular …, 2020 - nature.com
Obsessive compulsive disorder (OCD) and major depressive disorder (MDD) are common,
often refractory, neuropsychiatric conditions for which new treatment approaches are …

[HTML][HTML] A study of novel bilateral thermal capsulotomy with focused ultrasound for treatment-refractory obsessive–compulsive disorder: 2-year follow-up

SJ Kim, D Roh, HH Jung, WS Chang… - Journal of psychiatry …, 2018 - ncbi.nlm.nih.gov
Background Recently, a new thermal lesioning approach using magnetic resonance–guided
focused ultrasound (MRgFUS) was introduced for the treatment of neurologic disorders …

Ablative brain surgery: an overview

A Franzini, S Moosa, D Servello, I Small… - International Journal …, 2019 - Taylor & Francis
Background: Ablative therapies have been used for the treatment of neurological disorders
for many years. They have been used both for creating therapeutic lesions within …

Dissecting OCD circuits: from animal models to targeted treatments

SE Ahmari, DD Dougherty - Depression and anxiety, 2015 - Wiley Online Library
Obsessive–compulsive disorder (OCD) is a chronic, severe mental illness with up to 2–3%
prevalence worldwide. In fact, OCD has been classified as one of the world's 10 leading …