This review is concerned with the role of fibrillization of the amyloid β (Aβ)-peptide in
Alzheimer's disease (AD). The perspective is that of a physical chemist, and one aim is to …

Ordered protein aggregation in the brain is a hallmark of Alzheimer's disease and scrapie.
The disease-specific amyloid fibrils comprise primarily a single protein, amyloid β, in …

We have developed a statistical mechanics algorithm, TANGO, to predict protein
aggregation. TANGO is based on the physico-chemical principles of β-sheet formation …

Publisher Summary Despite the presence of a significant amount of carbohydrate in these
fibrils, the staining reaction was eventually shown to be because of the protein component …

Aggregation results in the formation of inclusion bodies, amyloid fibrils and folding
aggregates. Substantial data support the hypothesis that partially folded intermediates are …

Amyloid β-protein (Aβ) oligomers may be the proximate neurotoxins in Alzheimer's disease
(AD).“Oligomer” is an ill-defined term because many kinds have been reported and they …

Inhibition of the accumulation of amyloid β‐peptide (Aβ) and the formation of β‐amyloid
fibrils (fAβ) from Aβ, as well as the destabilization of preformed fAβ in the central nervous …

Parkinson's disease involves the aggregation of α-synuclein to form fibrils, which are the
major constituent of intracellular protein inclusions (Lewy bodies and Lewy neurites) in …

Protein aggregation is an important phenomenon that alternatively is part of the normal
functioning of nature or, central to this review, has negative consequences via its …

Alzheimer's disease is characterized by extensive cerebral amyloid deposition. Amyloid
deposits associated with damaged neuropil and blood vessels contain abundant fibrils …