The conformational cycle of prestin underlies outer-hair cell electromotility
The voltage-dependent motor protein prestin (also known as SLC26A5) is responsible for
the electromotive behaviour of outer-hair cells and underlies the cochlear amplifier …
the electromotive behaviour of outer-hair cells and underlies the cochlear amplifier …
Molecular mechanism of prestin electromotive signal amplification
Hearing involves two fundamental processes: mechano-electrical transduction and signal
amplification. Despite decades of studies, the molecular bases for both remain elusive …
amplification. Despite decades of studies, the molecular bases for both remain elusive …
Prestin at year 14: progress and prospect
Prestin, the motor protein of cochlear outer hair cells, was identified 14 years ago. Prestin-
based outer hair cell motility is responsible for the exquisite sensitivity and frequency …
based outer hair cell motility is responsible for the exquisite sensitivity and frequency …
Single particle cryo-EM structure of the outer hair cell motor protein prestin
C Butan, Q Song, JP Bai, WJT Tan… - Nature …, 2022 - nature.com
The mammalian outer hair cell (OHC) protein prestin (Slc26a5) differs from other Slc26
family members due to its unique piezoelectric-like property that drives OHC electromotility …
family members due to its unique piezoelectric-like property that drives OHC electromotility …
[HTML][HTML] Microtubule and auditory function–an underestimated connection
L Bieniussa, I Jain, MB Grau, L Juergens… - Seminars in Cell & …, 2023 - Elsevier
The organ of Corti, located in the cochlea within the inner ear is the receptor organ for
hearing. It converts auditory signals into neuronal action potentials that are transmitted to the …
hearing. It converts auditory signals into neuronal action potentials that are transmitted to the …
A genetically-encoded YFP sensor with enhanced chloride sensitivity, photostability and reduced ph interference demonstrates augmented transmembrane chloride …
Background Chloride is the major anion in cells, with many diseases arising from disordered
Cl− regulation. For the non-invasive investigation of Cl− flux, YFP-H148Q and its derivatives …
Cl− regulation. For the non-invasive investigation of Cl− flux, YFP-H148Q and its derivatives …
Prestin amplifies cardiac motor functions
Cardiac cells generate and amplify force in the context of cardiac load, yet the membranous
sheath enclosing the muscle fibers—the sarcolemma—does not experience displacement …
sheath enclosing the muscle fibers—the sarcolemma—does not experience displacement …
Complex nonlinear capacitance in outer hair cell macro-patches: effects of membrane tension
J Santos-Sacchi, W Tan - Scientific Reports, 2020 - nature.com
Outer hair cell (OHC) nonlinear capacitance (NLC) represents voltage sensor charge
movements of prestin (SLC26a5), the protein responsible for OHC electromotility. Previous …
movements of prestin (SLC26a5), the protein responsible for OHC electromotility. Previous …
[HTML][HTML] Prestin derived OHC surface area reduction underlies age‐related rescaling of frequency place coding
Outer hair cells (OHC) are key to the mammalian cochlear amplifier, powered by the lateral
membrane protein Prestin. In this study, we explored age-related OHC changes and how the …
membrane protein Prestin. In this study, we explored age-related OHC changes and how the …
[HTML][HTML] Hearing consequences in Gjb2 knock-in mice: implications for human p. V37I mutation
X Lin, G Li, Y Zhang, J Zhao, J Lu, Y Gao, H Liu… - Aging (Albany …, 2019 - ncbi.nlm.nih.gov
Human p. V37I mutation of GJB2 gene was strongly correlated with late-onset progressive
hearing loss, especially among East Asia populations. We generated a knock-in mouse …
hearing loss, especially among East Asia populations. We generated a knock-in mouse …