Maturation of mRNA precursors often occurs simultaneously with their synthesis by RNA
polymerase II (Pol II). The co-transcriptional nature of mRNA processing has permitted the …

The C-terminal domain (CTD) of the RNA polymerase II largest subunit consists of multiple
heptad repeats (consensus Tyr1–Ser2–Pro3–Thr4–Ser5–Pro6–Ser7), varying in number …

Appreciable advances into the process of transcript elongation by RNA polymerase II (RNAP
II) have identified this stage as a dynamic and highly regulated step of the transcription …

Gene transcription in the cell nucleus is a complex and highly regulated process.
Transcription in eukaryotes requires three distinct RNA polymerases, each of which employs …

Most eukaryotic mRNA precursors (premRNAs) must undergo extensive processing,
including cleavage and polyadenylation at the 3′-end. Processing at the 3′-end is …

The cycle of eukaryotic transcription, from initiation to elongation and termination is
regulated at multiple steps. Coordinated action of regulatory factors keeps in check the …

Background Alternative polyadenylation is one of the mechanisms in human cells that give
rise to a variety of transcripts from a single gene. More than half of the human genes have …

Mechanistic analysis of transcriptional initiation and termination by RNA polymerase II (PolII)
indicates that some factors are common to both processes,. Here we show that two long …

Recent advances in understanding the molecular mechanism of mRNA 3′ end cleavage
and polyadenylation have uncovered an unanticipated involvement of this process in the …

Abstract Phosphorylation of serine-2 (S2) and serine-5 (S5) of the C-terminal domain (CTD)
of RNA polymerase II (RNAP II) is a dynamic process that regulates the transcription cycle …