Background Polypharmacy is a prevalent condition in older adults, especially those with
multiple chronic diseases, and has been largely associated with adverse outcomes …

Fluoxetine is still one of the most widely used antidepressants in the world. The drug is
extensively metabolized by several cytochrome P450 (CYP450) enzymes and subjected to a …

Introduction Given the lack of real-world data on oral semaglutide use outside clinical trials,
the purpose of this study was to describe dose, prescriber specialty, and change in …

我国正进入老龄化阶段, 老年人药代动力学及药效学下降极易引起药物体内蓄积产生药物相关
不良反应. 老年人多病共存现象普遍, 多重用药及潜在不恰当用药(potential inappropriate …

Patients with type 2 diabetes (T2D) frequently have multiple cardiovascular, metabolic, and
renal comorbidities, such as hypertension, dyslipidemia, hyperuricemia, chronic kidney …

Aims The aims of this study were to estimate potentially clinically important drug–drug
interaction (DDI) prevalence, and the average causal effect of DDI exposure on adverse …

Comorbidity rates in the geriatric population have increased because of rising life
expectancy; thus, patients have had to use more medications. Type 2 diabetes mellitus, one …

Objectives The purpose of this study was to systematically assess existing studies to
demonstrate the association between potentially inappropriate medication (PIM) and frailty …

The objection of this study was to investigate the effects of vindoline (VDL) on the
cytochrome P450 (CYP 450) isoforms (CYP1A2, 2B, 2C11, 2D1 and 3A) in rats. Firstly, the …

ABSTRACT Aims/Introduction Polypharmacy in diabetes patients is related to worse clinical
outcomes. The aim of this study was to evaluate the usefulness of our countermeasure for …