Some antibiotics that are frequently employed are β-lactams. In light of the hydrolytic
process of β-lactamase, found in Gram-negative bacteria, inhibitors of β-lactamase (BLIs) …

The discovery of β-lactam (BL) antibiotics in the early 20th century represented a remarkable
advancement in human medicine, allowing for the widespread treatment of infectious …

Addressing antibacterial resistance is a major concern of the modern world. The
development of new approaches to meet this deadly threat is a critical priority. In this article …

In an attempt to exploit the hydrolytic mechanism by which β-lactamases degrade
cephalosporins, we designed and synthesized a series of novel cephalosporin prodrugs …

L1 is a dizinc subclass B3 metallo-β-lactamase (MBL) that hydrolyzes most β-lactam
antibiotics and is a key resistance determinant in the Gram-negative pathogen …

Background/Objectives: Among various carbapenemases, New Delhi metallo-beta-
lactamases (NDMs) are recognized as the most powerful type capable of hydrolyzing all …

β-lactams are the most prescribed class of antibiotics due to their potent, broad-spectrum
antimicrobial activities. However, alarming rates of antimicrobial resistance now threaten the …

Cefiderocol is the first approved catechol-conjugated cephalosporin against multidrug-
resistant Gram-negative bacteria, while its application was limited by poor chemical stability …

Abstract The emergence of New Delhi metallo-β-lactamase-1 (NDM-1) poses a significant
threat to the clinical application of antibiotics, as it possesses the ability to hydrolyze nearly …

The wide spread of metallo-β-lactamase (MBL)-expressing bacteria has greatly threatened
human health, and there is an urgent need for inhibitors against MBLs. Herein, we present a …