Functioning and mechanisms of PTMs in renal diseases

Z Liu, J Yang, M Du, W Xin - Frontiers in Pharmacology, 2023 - frontiersin.org
Post-translational modifications (PTMs) are crucial epigenetic mechanisms that regulate
various cellular biological processes. The use of mass spectrometry (MS)-proteomics has …

Human O-GlcNAcase Uses a Preactivated Boat-skew Substrate Conformation for Catalysis. Evidence from X-ray Crystallography and QM/MM Metadynamics

M Calvelo, A Males, MG Alteen, LI Willems… - ACS …, 2023 - ACS Publications
Human O-linked β-N-acetylglucosaminidase (hOGA) is one of the two enzymes involved in
nuclear and cytoplasmic protein O-GlcNAcylation, an essential post-translational …

C-Ribosylating Enzymes in the (Bio)Synthesis of C-Nucleosides and C-Glycosylated Natural Products

M Pfeiffer, B Nidetzky - ACS Catalysis, 2023 - ACS Publications
Small-molecule glycosides that exhibit a β-d-ribosyl residue linked to an aglycone via a
noncanonical C-glycosidic linkage are of great biological importance. They occur naturally …

[HTML][HTML] A Refined Nomenclature System to Better Discriminate Endo-and Exo-Type Fructanases and Glucanases

L Leaerts, JR Porras-Domínguez, M Versluys… - Biomolecules, 2024 - mdpi.com
Distinguishing between endo-and exo-type enzymes within the glycoside hydrolase (GH)
classification presents significant challenges. Traditional methods, often based on endpoint …

[图书][B] Advances in carbohydrate chemistry and biochemistry

D Horton - 2012 - books.google.com
Since its inception in 1945, this serial has provided critical and integrating articles written by
research specialists that integrate industrial, analytical, and technological aspects of …

Activity-dependent glassy cell mechanics II: Nonthermal fluctuations under metabolic activity

K Umeda, K Nishizawa, W Nagao, S Inokuchi… - Biophysical …, 2023 - cell.com
The glassy cytoplasm, crowded with bio-macromolecules, is fluidized in living cells by
mechanical energy derived from metabolism. Characterizing the living cytoplasm as a …

Two-step computational redesign of Bacillus subtilis cellulase and β-glucanase for enhanced thermostability and activity

H Zhang, T Zhu, Q Zhai, Q Chen, X Zhang… - International Journal of …, 2025 - Elsevier
The growing demand for biocatalysts in biomass processing highlights the necessity of
enhancing the thermostability of glycoside hydrolases. However, improving both …

[HTML][HTML] Borylated Monosaccharide 3-Boronic-3-deoxy-d-galactose: Detailed NMR Spectroscopic Characterisation, and Method for Spectroscopic Analysis of …

M Simone - International Journal of Molecular Sciences, 2024 - mdpi.com
Drug leads with a high Fsp3 index are more likely to possess desirable properties for
progression in the drug development pipeline. This paper describes the first detailed NMR …

Structural and molecular insights into a bifunctional glycoside hydrolase 30 xylanase specific to glucuronoxylan

C Pentari, C Kosinas, E Nikolaivits… - Biotechnology and …, 2024 - Wiley Online Library
Glycoside hydrolase (GH) 30 family xylanases are enzymes of biotechnological interest due
to their capacity to degrade recalcitrant hemicelluloses, such as glucuronoxylan (GX). This …

[PDF][PDF] Computational modeling of protein–carbohydrate interactions: Current trends and future challenges

S Pérez - Advances in Carbohydrate Chemistry and Biochemistry, 2023 - hal.science
AA all-atom Aβ amyloid CD44 a cell-surface glycoprotein CG coarse-grained DAG
diacylglycerol DFT density functional theory MGD1monogalactosyldiacylglycerol synthase …