TAM receptor signaling in immune homeostasis
CV Rothlin, EA Carrera-Silva, L Bosurgi… - Annual review of …, 2015 - annualreviews.org
The TAM receptor tyrosine kinases (RTKs)—T YRO3, A XL, and M ERTK—together with their
cognate agonists GAS6 and PROS1 play an essential role in the resolution of inflammation …
cognate agonists GAS6 and PROS1 play an essential role in the resolution of inflammation …
[HTML][HTML] Diagnosis and treatment of chronic myelomonocytic leukemias in adults: recommendations from the European Hematology Association and the European …
R Itzykson, P Fenaux, D Bowen, NCP Cross… - …, 2018 - journals.lww.com
Chronic myelomonocytic leukemia (CMML) is a disease of the elderly, and by far the most
frequent overlap myelodysplastic/myeloproliferative neoplasm in adults. Aside from the …
frequent overlap myelodysplastic/myeloproliferative neoplasm in adults. Aside from the …
Mer regulates microglial/macrophage M1/M2 polarization and alleviates neuroinflammation following traumatic brain injury
Background Traumatic brain injury (TBI) is a leading cause of death and disability
worldwide. Microglial/macrophage activation and neuroinflammation are key cellular events …
worldwide. Microglial/macrophage activation and neuroinflammation are key cellular events …
The role of TAM family receptors in immune cell function: implications for cancer therapy
M Paolino, JM Penninger - Cancers, 2016 - mdpi.com
The TAM receptor protein tyrosine kinases—Tyro3, Axl, and Mer—are essential regulators of
immune homeostasis. Guided by their cognate ligands Growth arrest-specific gene 6 (Gas6) …
immune homeostasis. Guided by their cognate ligands Growth arrest-specific gene 6 (Gas6) …
The cardiac microenvironment instructs divergent monocyte fates and functions in myocarditis
Two types of monocytes, Ly6C hi and Ly6C lo, infiltrate the heart in murine experimental
autoimmune myocarditis (EAM). We discovered a role for cardiac fibroblasts in facilitating …
autoimmune myocarditis (EAM). We discovered a role for cardiac fibroblasts in facilitating …
CD16+ Monocyte Subset Was Enriched and Functionally Exacerbated in Driving T-Cell Activation and B-Cell Response in Systemic Lupus Erythematosus
H Zhu, F Hu, X Sun, X Zhang, L Zhu, X Liu, X Li… - Frontiers in …, 2016 - frontiersin.org
Background The roles that CD16+ monocyte subset plays in T-cell activation and B-cell
response have not been well studied in systemic lupus erythematosus (SLE). Objective The …
response have not been well studied in systemic lupus erythematosus (SLE). Objective The …
Receptor tyrosine kinases Tyro3, Axl, and Mertk differentially contribute to antibody-induced arthritis
L Gao, C He, A Yang, H Zhou, Q Lu, RB Birge… - Cell Communication and …, 2023 - Springer
Abstract Tyro3, Axl, and Mertk (abbreviated TAMs) comprise a family of homologous type 1
receptor tyrosine kinases (RTKs) that have been implicated as inhibitory receptors that …
receptor tyrosine kinases (RTKs) that have been implicated as inhibitory receptors that …
The PPAR-γ antagonist GW9662 elicits differentiation of M2c-like cells and upregulation of the MerTK/Gas6 axis: a key role for PPAR-γ in human macrophage …
Background The nuclear receptors PPAR-γ and LXRs regulate macrophage lipid
metabolism and macrophage mediated inflammation. We examined the influence of these …
metabolism and macrophage mediated inflammation. We examined the influence of these …
Contribution of defective PS recognition and efferocytosis to chronic inflammation and autoimmunity
The rapid and efficient clearance of apoptotic cells results in the elimination of auto-antigens
and provides a strong anti-inflammatory and immunosuppressive signal to prevent …
and provides a strong anti-inflammatory and immunosuppressive signal to prevent …
TAM-ing T cells in the tumor microenvironment: implications for TAM receptor targeting
MJW Peeters, A Rahbech, P thor Straten - Cancer Immunology …, 2020 - Springer
Abstract The TAM receptors—TYRO3, AXL, MERTK—are pleiotropically expressed
receptors in both healthy and diseased tissue. A complex of the ligands Protein S (PROS1) …
receptors in both healthy and diseased tissue. A complex of the ligands Protein S (PROS1) …