Oligodendrocyte death and myelin loss in the cuprizone model: an updated overview of the intrinsic and extrinsic causes of cuprizone demyelination
Background The dietary consumption of cuprizone–a copper chelator–has long been known
to induce demyelination of specific brain structures and is widely used as model of multiple …
to induce demyelination of specific brain structures and is widely used as model of multiple …
[HTML][HTML] Cellular and molecular neuropathology of the cuprizone mouse model: clinical relevance for multiple sclerosis
J Praet, C Guglielmetti, Z Berneman… - Neuroscience & …, 2014 - Elsevier
The cuprizone mouse model allows the investigation of the complex molecular mechanisms
behind nonautoimmune-mediated demyelination and spontaneous remyelination. While it is …
behind nonautoimmune-mediated demyelination and spontaneous remyelination. While it is …
[HTML][HTML] Metallobiology and therapeutic chelation of biometals (copper, zinc and iron) in Alzheimer's disease: Limitations, and current and future perspectives
Background Alzheimer's disease (AD) is the most prevalent cause of cognitive impairment
and dementia worldwide. The pathobiology of the disease has been studied in the form of …
and dementia worldwide. The pathobiology of the disease has been studied in the form of …
Application of metal coordination chemistry to explore and manipulate cell biology
Our desire to understand how the individual molecules that make up cells organize, interact,
and communicate to form living systems has led to the burgeoning field of chemical biology …
and communicate to form living systems has led to the burgeoning field of chemical biology …
The cuprizone animal model: new insights into an old story
M Kipp, T Clarner, J Dang, S Copray, C Beyer - Acta neuropathologica, 2009 - Springer
Multiple sclerosis (MS) is a chronic, inflammatory, demyelinating disease that affects the
central nervous system and represents the most common neurological disorder in young …
central nervous system and represents the most common neurological disorder in young …
The cuprizone model: dos and do nots
Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central
nervous system. Various pre-clinical models with different specific features of the disease …
nervous system. Various pre-clinical models with different specific features of the disease …
Cotton metallothionein GhMT3a, a reactive oxygen species scavenger, increased tolerance against abiotic stress in transgenic tobacco and yeast
T Xue, X Li, W Zhu, C Wu, G Yang… - Journal of experimental …, 2009 - academic.oup.com
A cDNA clone encoding a 64-amino acid type 3 metallothionein protein, designated
GhMT3a, was isolated from cotton (Gossypium hirsutum) by cDNA library screening …
GhMT3a, was isolated from cotton (Gossypium hirsutum) by cDNA library screening …
Redox metals homeostasis in multiple sclerosis and amyotrophic lateral sclerosis: a review
The effect of redox metals such as iron and copper on multiple sclerosis and amyotrophic
lateral sclerosis has been intensively studied. However, the origin of these disorders …
lateral sclerosis has been intensively studied. However, the origin of these disorders …
Animal models to investigate the effects of inflammation on remyelination in multiple sclerosis
M Gharagozloo, JW Mace… - Frontiers in Molecular …, 2022 - frontiersin.org
Multiple sclerosis (MS) is a chronic inflammatory, demyelinating, and neurodegenerative
disease of the central nervous system (CNS). In people with MS, impaired remyelination and …
disease of the central nervous system (CNS). In people with MS, impaired remyelination and …
Behavioural phenotypes in the cuprizone model of central nervous system demyelination
The feeding of cuprizone (CPZ) to animals has been extensively used to model the
processes of demyelination and remyelination, with many papers adopting a narrative linked …
processes of demyelination and remyelination, with many papers adopting a narrative linked …