Fragile X syndrome (FXS), a heritable intellectual and autism spectrum disorder (ASD),
results from the loss of Fragile X mental retardation protein (FMRP). This …

Fragile X syndrome (FXS) is the most common form of monogenic hereditary cognitive
impairment. FXS patient exhibit a high comorbidity rate with autism spectrum disorders …

Learning and memory rely on long-lasting, synapse-specific modifications. Although
postsynaptic forms of plasticity typically require local protein synthesis, whether and how …

Developing synapses mature through the recruitment of specific proteins that stabilize
presynaptic and postsynaptic structure and function. Wnt ligands signaling via Frizzled (Fz) …

Fragile X syndrome (FXS) is the most frequent inherited cause of intellectual disability and
the best-studied monogenic cause of autism. FXS results from the functional absence of the …

The hippocampal mossy fiber synapse, formed between axons of dentate gyrus granule
cells and dendrites of CA3 pyramidal neurons, is a key synapse in the trisynaptic circuitry of …

Unrelated genetic mutations can lead to convergent manifestations of neurological disorders
with similar behavioral phenotypes. Experimental data frequently show a lack of dramatic …

Bisphenol A (BPA) is a ubiquitous environmental chemical that has been linked to
behavioral differences in children and shown to impact critical neurodevelopmental …

The transcription factor Bcl11b has been linked to neurodevelopmental and
neuropsychiatric disorders associated with synaptic dysfunction. Bcl11b is highly expressed …

Profilins are small actin binding proteins, which are structurally conserved throughout
evolution. They are probably best known to promote and direct actin polymerization …