Inherited retinal diseases (IRDs) are a clinically complex and heterogenous group of visual
impairment phenotypes caused by pathogenic variants in at least 277 nuclear and …

A century ago, Cajal noted striking similarities between the neural circuits that underlie
vision in vertebrates and flies. Over the past few decades, structural and functional studies …

In the developing vertebrate retina, diverse neuronal subtypes originate from multipotent
progenitors in a conserved order and are integrated into an intricate laminated architecture …

Breast cancer is the most common type of cancer worldwide and one of the major causes of
cancer death in women. Epidemiological studies have established a link between night-shift …

X-linked juvenile retinoschisis (XLRS, MIM 312700) is a common early onset macular
degeneration in males characterized by mild to severe loss in visual acuity, splitting of retinal …

Humans rely on visual cues to navigate the world around them. Vision begins with the
detection of light by photoreceptor cells in the retina, a light-sensitive tissue located at the …

Development of efficacious in vivo delivery platforms for CRISPR-Cas9-based epigenome
engineering will be critical to enable the ability to target human diseases without permanent …

Centrosome-and cilia-associated proteins play crucial roles in establishing polarity and
regulating intracellular transport in post-mitotic cells. Using genetic mapping and positional …

Nephronophthisis (NPHP) is the most frequent genetic cause of chronic renal failure in
children,,. Identification of four genes mutated in NPHP subtypes 1–4 (refs.–) has linked the …

Photoreceptors–the light-sensitive cells in the vertebrate retina–have been extremely well-
characterized with regards to their biochemistry, cell biology and physiology. They therefore …