Uptake of low-density lipoprotein (LDL) particles by macrophages represents a key step in
the development of atherosclerotic plaques, leading to the foam cell formation. Chemical …

High-density lipoproteins (HDL) possess key atheroprotective biological properties,
including cellular cholesterol efflux capacity, and anti-oxidative and anti-inflammatory …

Cells are richly equipped with nuclear receptors, which act as ligand-regulated transcription
factors. Peroxisome proliferator activated receptors (PPARs), members of the nuclear …

The paraoxonase (PON) gene family is composed of three members (PON1, PON2, PON3)
that share considerable structural homology and are located adjacently on chromosome 7 in …

To investigate the influence of Moringa seed extract (MSE) on the cerebral Nrf2/NQO1
signaling in TiO 2-NPs–induced brain damage, 80 male albino rats were divided into four …

High density lipoprotein (HDL) has many properties, which contribute to its atheroprotective
role. However, some recent clinical trials have identified subjects with the progression of …

Background Decreased activity of the enzyme paraoxonase-1 (PON1) has been
demonstrated in cardiovascular diseases. Statins, the forefront of pharmacotherapy for …

Growing evidences demonstrated that zinc oxide nanoparticles (ZnONPs) could reach the
brain after oral ingestion; however, the “neurotoxicity of” ZnONPs after oral exposure has not …

BACKGROUND: Paraoxonase enzyme was first identified as a protective barrier against
organophosphorus poisoning. After painstaking research spanning the last three decades …

There is increasing evidence that human atherosclerosis is associated with damage to the
DNA of both circulating cells, and cells of the vessel wall. Reactive oxygen species are the …