Murine and human systemic lupus erythematosus (SLE, lupus) is characterized by the
appearance of autoantibodies directed to nuclear and cell membrane phospholipid …

Systemic lupus erythematosus (SLE) is a multifaceted autoimmune disease characterized by
the production of pathogenic immunoglobulins, such as antinuclear and antiphospholipid …

We investigated the role of the costimulatory molecules, CD40 and its ligand CD40L, in the
pathogenesis of human SLE. In comparison to normal subjects or patients in remission …

Only a fraction (12%) of 268" autoreactive" T cell clones derived from lupus-prone mice can
selectively induce the production of pathogenic anti-DNA autoantibodies in vitro and …

On the lupus-prone MRL-lpr/lpr (MRL-lpr) background, AM14 rheumatoid factor (RF) B cells
are activated, differentiate into plasmablasts, and undergo somatic hypermutation outside of …

We tested 154 peptides spanning the entire length of core histones of nucleosomes for the
ability to stimulate an anti-DNA autoantibody–inducing T helper (Th) clone, as well as CD4+ …

Nucleosome-specific T helper (Th) cells provide major histocompatibility complex class II-
restricted, cognate help to nephritogenic antinuclear autoantibody-producing B cells in …

The complexity and chronicity of parasitic infections have obscured the identification of
biologically relevant antigens. Analysis of the T cell receptor repertoire used by mice …

The production of potentially pathogenic anti-DNA autoantibodies in SLE is driven by
special, autoimmune T helper (Th) cells. Herein, we sequenced the T cell receptor (TCR) …

Abstract In the (SWR× NZB) F 1 mouse model of lupus, we previously localized the critical
autoepitopes for nephritogenic autoantibody-inducing Th cells in the core histones of …