Cerebrospinal fluid analyses and neuroimaging can identify the underlying pathophysiology
at the earliest stage of some neurodegenerative disorders, but do not have the scalability …

Although behavioral variant frontotemporal dementia (bvFTD) is classically defined by
behavioral and socio-emotional changes, impairments often extend to other cognitive …

Dementia, a chronic and progressive cognitive declination of brain function caused by
disease or impairment, is becoming more prevalent due to the aging population. A major …

Brain aging is a complex process that includes atrophy, vascular injury, and a variety of age-
associated neurodegenerative pathologies, together determining an individual's course of …

Background/aims In this multicentre study in clinical settings, we assessed the accuracy of
optimized procedures for FDG-PET brain metabolism and CSF classifications in predicting …

Background Previous research has described distinct subtypes of Alzheimer's disease (AD)
based on the differences in regional patterns of brain atrophy on MRI. We conducted a data …

Frontotemporal dementia encompasses a group of clinical syndromes defined
pathologically by degeneration of the frontal and temporal lobes. Historically, these …

Cognitive reserve (CR) and brain reserve (BR) are protective factors against age‐associated
cognitive decline and neurodegenerative disorders. Very limited evidence exists about …

Positron emission tomography (PET) represents a unique molecular tool to get in vivo
access to a wide spectrum of biological and neuropathological processes, of crucial …

Disinhibition, mainly caused by damage in frontotemporal brain regions, is one of the major
causes of caregiver distress in neurodegenerative dementias. Behavioural inhibition deficits …