Menin inhibitors are novel targeted agents currently in clinical development for the treatment
of genetically defined subsets of acute leukemia. Menin has a tumor suppressor function in …

The homeobox (HOX) genes are a highly conserved family of homeodomain-containing
transcription factors that specify cell identity in early development and, subsequently, in a …

Targeting critical epigenetic regulators reverses aberrant transcription in cancer, thereby
restoring normal tissue function,–. The interaction of menin with lysine methyltransferase 2A …

Background Family history is a significant risk factor for prostate cancer, although the
molecular basis for this association is poorly understood. Linkage studies have implicated …

PURPOSE Revumenib, an oral, small molecule inhibitor of the menin-lysine
methyltransferase 2A (KMT2A) interaction, showed promising efficacy and safety in a phase …

Gene expression analyses, gene targeting experiments and retroviral overexpression
studies in the murine bone marrow transplantation model have provided strong correlative …

The polycomb repressive complex (PRC) 2 contains 3 core proteins, EZH2, SUZ12, and
EED, in which the SET (suppressor of variegation–enhancer of zeste-trithorax) domain of …

Leukemias that harbor translocations involving the mixed lineage leukemia gene (MLL)
possess unique biologic characteristics and often have an unfavorable prognosis. Gene …

The HOM‐C clustered prototype homeobox genes of Drosophila, and their counterparts, the
HOX genes in humans, are highly conserved at the genomic level. These master regulators …

MLL fusion proteins are oncogenic transcription factors that are associated with aggressive
lymphoid and myeloid leukemias. We constructed an inducible MLL fusion, MLL-ENL-ERtm …