This is the second of the two White Papers from the fourth UC Davis Cardiovascular
Symposium Systems Approach to Understanding Cardiac Excitation–Contraction Coupling …

In the chronic stage of myocardial infarction, a significant number of patients develop life-
threatening ventricular tachycardias (VT) due to the arrhythmogenic nature of the remodeled …

Rationale: Myocardial delivery of human mesenchymal stem cells (hMSCs) is an emerging
therapy for treating the failing heart. However, the relative effects of hMSC-mediated …

Background: Atrial fibrillation (AF), the most common cardiac arrhythmia, is characterized by
alteration of the action potential (AP) propagation. Under persistent AF, myocytes undergo …

The monodomain model is widely used in in‐silico cardiology to describe excitation
propagation in the myocardium. Frequently, operator splitting is used to decouple the stiff …

Background Heart failure is a final common pathway or descriptor for various cardiac
pathologies. It is associated with sudden cardiac death, which is frequently caused by …

Atrial fibrillation (AF) is associated with atrial remodeling, cardiac dysfunction, and poor
clinical outcomes. External direct current electrical cardioversion is a well-developed urgent …

Remodeling in atrial fibrillation (AF) underlines the electrical and structural changes in the
atria, where fibrosis is a hallmark of arrhythmogenic structural alterations. Fibrosis is an …

Purpose Diffuse remodeling of myocardial extra-cellular matrix is largely responsible for left
ventricle (LV) dysfunction and arrhythmias. Our hypothesis is that the texture analysis of late …

Age-related fibrosis in the left ventricle (LV) has been mainly studied in animals by
assessing collagen content. Using second-harmonic generation microscopy and image …