Mechanisms of abscisic acid-mediated drought stress responses in plants

M Muhammad Aslam, M Waseem, BH Jakada… - International journal of …, 2022 - mdpi.com
Drought is one of the major constraints to rain-fed agricultural production, especially under
climate change conditions. Plants evolved an array of adaptive strategies that perceive …

Natural products: A lead for drug discovery and development

B Chopra, AK Dhingra - Phytotherapy Research, 2021 - Wiley Online Library
Natural products are used since ancient times in folklore for the treatment of various
ailments. Plant‐derived products have been recognized for many years as a source of …

Effects of polyethylene and polylactic acid microplastics on plant growth and bacterial community in the soil

Y Lian, W Liu, R Shi, A Zeb, Q Wang, J Li… - Journal of Hazardous …, 2022 - Elsevier
Abstract Microplastics (MPs), especially biodegradable MPs (BMPs) have attracted
increasing attention in recent years. However, the effects of MPs with different …

Untargeted metabolomics strategies—challenges and emerging directions

AC Schrimpe-Rutledge, SG Codreanu… - Journal of the …, 2016 - ACS Publications
Metabolites are building blocks of cellular function. These species are involved in enzyme-
catalyzed chemical reactions and are essential for cellular function. Upstream biological …

MetaboAnalystR 2.0: from raw spectra to biological insights

J Chong, M Yamamoto, J Xia - Metabolites, 2019 - mdpi.com
Global metabolomics based on high-resolution liquid chromatography mass spectrometry
(LC-MS) has been increasingly employed in recent large-scale multi-omics studies …

Machine learning applications for mass spectrometry-based metabolomics

UW Liebal, ANT Phan, M Sudhakar, K Raman… - Metabolites, 2020 - mdpi.com
The metabolome of an organism depends on environmental factors and intracellular
regulation and provides information about the physiological conditions. Metabolomics helps …

Big data for health

J Andreu-Perez, CCY Poon… - IEEE journal of …, 2015 - ieeexplore.ieee.org
This paper provides an overview of recent developments in big data in the context of
biomedical and health informatics. It outlines the key characteristics of big data and how …

Metabolomics in the context of plant natural products research: From sample preparation to metabolite analysis

MA Salem, L Perez de Souza, A Serag, AR Fernie… - Metabolites, 2020 - mdpi.com
Plant-derived natural products have long been considered a valuable source of lead
compounds for drug development. Natural extracts are usually composed of hundreds to …

A tutorial review: Metabolomics and partial least squares-discriminant analysis–a marriage of convenience or a shotgun wedding

PS Gromski, H Muhamadali, DI Ellis, Y Xu, E Correa… - Analytica chimica …, 2015 - Elsevier
The predominance of partial least squares-discriminant analysis (PLS-DA) used to analyze
metabolomics datasets (indeed, it is the most well-known tool to perform classification and …

Challenges and emergent solutions for LC‐MS/MS based untargeted metabolomics in diseases

L Cui, H Lu, YH Lee - Mass spectrometry reviews, 2018 - Wiley Online Library
In the past decade, advances in liquid chromatography‐mass spectrometry (LC‐MS) have
revolutionized untargeted metabolomics analyses. By mining metabolomes more deeply …