Most of the genes in the major histocompatibility complex (MHC) region express high
polymorphism that is fundamental for their function. The most important function of human …

A key issue in the treatment of many cancers is the development of resistance to
chemotherapeutic drugs. Resistance mechanisms are numerous and complex. One of them …

In the late 1980s and early 1990s, the hunt for a transporter molecule ostensibly responsible
for the translocation of peptides across the endoplasmic reticulum (ER) membrane yielded …

Inborn errors of immunity (IEI) are a heterogenous group of disorders driven by genetic
defects that functionally impact the development and/or function of the innate and/or …

Deficiencies of MHC complex class I or II are rare primary immunodeficiencies, both of which
are inherited in an autosomal recessive pattern. MHC class II deficiency is a prototype of a …

Background Most patients with MHC class I (MHC-I) deficiency carry genetic defects in
transporter associated with antigen processing 1 (TAP1) or TAP2. The clinical presentation …

Herpesviruses are large DNA viruses that are highly abundant within their host populations.
Even in the presence of a healthy immune system, these viruses manage to cause lifelong …

Human leukocyte antigen (HLA) class I deficiency is a rare disease with remarkable clinical
and biological heterogeneity. The spectrum of possible manifestations extends from the …

Coevolution of herpesviruses and their hosts has driven the development of both host
antiviral mechanisms to detect and eliminate infected cells and viral ploys to escape immune …

Human primary immunodeficiency (PID) states, where mutations in single immune system
genes predispose individuals to certain infectious agents and not others, are experiments of …