The quality of fetal growth and development predicts the risk for a range of
noncommunicable, chronic illnesses. These observations form the basis of the …

The past five years have seen many scientific and biological discoveries made through the
experimental design of genome-wide association studies (GWASs). These studies were …

Birth weight variation is influenced by fetal and maternal genetic and non-genetic factors,
and has been reproducibly associated with future cardio-metabolic health outcomes. In …

Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic
outcomes, independent of overall adiposity. To increase our understanding of the genetic …

Mendelian randomisation (MR) estimates causal effects of modifiable phenotypes on an
outcome by using genetic variants as instrumental variables, but its validity relies on the …

Abstract The Generation R Study is a population-based prospective cohort study from fetal
life until adulthood. The study is designed to identify early environmental and genetic causes …

Sequence-based variation in gene expression is a key driver of disease risk. Common
variants regulating expression in cis have been mapped in many expression quantitative …

Background Despite evidence that genetic factors contribute to the duration of gestation and
the risk of preterm birth, robust associations with genetic variants have not been identified …

Importance Neonates born to overweight or obese women are larger and at higher risk of
birth complications. Many maternal obesity-related traits are observationally associated with …

The Western Australian Pregnancy Cohort (Raine) Study (www. rainestudy. org. au) was
established 1989-1991 with the then stated purpose: to develop a large cohort of Western …