The physiological importance of the liver is demonstrated by its unique and essential ability
to regenerate following extensive injuries affecting its function. By regenerating, the liver …

The maintenance of body homeostasis relies heavily on physiological barriers. Dysfunction
of these barriers can lead to various pathological processes, including increased exposure …

This study presents the development and validation of an innovative microfluidic liver-on-a-
chip device utilizing gravity-driven perfusion for the evaluation of drug hepatotoxicity. This …

Liver is responsible for the metabolization processes of up to 90% of compounds and toxins
in the body. Therefore liver-on-a-chip systems, as an in vitro promising cell culture platform …

Simple Summary This article provides a review of recent studies that explore the application
of the 3Rs in experimental animal models of liver disease, comparing different models for a …

Advances in microsystem engineering have enabled the development of highly controlled
models of the liver that better recapitulate the unique in vivo biological conditions. In just a …

Tannic acid (TA) has been used to treat diarrhea, local skin burns, and rectal diseases and
as a natural nonautogenous material in cell therapy. Since the ancient times, East Asian …

Research within the hepato-biliary system and hepatic function is currently experiencing
heightened interest, this is due to the high frequency of relapse rates observed in chronic …

The liver is the primary organ responsible for the detoxification and metabolism of drugs. To
date, a lack of preclinical models that accurately emulate drug metabolism by the human …

The liver produces and stores various nutrients that are necessary for the body and serves
as a chemical plant, metabolizing carbohydrates, fats, hormones, vitamins, and minerals. It is …