The gastrointestinal (GI) microbiome contributes significantly to host nutrition and health.
However, relationships involving GI microbes, their hosts and host macrohabitats remain to …

Histone acetyltransferases (HATs) and histone deacetylases (HDACs) are two opposing
classes of enzymes, which finely regulate the balance of histone acetylation affecting …

Abnormal synthesis and metabolism of sex steroids is involved in the pathogenesis of
various human diseases, such as endometriosis and cancers arising from the breast and …

The identification of novel genes involved in colorectal cancerogenesis is of high clinical
relevance for early diagnosis, applying new therapeutic strategies and monitoring disease …

Steroid hormones have been shown to play a role in gastric carcinogenesis. Large amounts
of steroid hormones are locally produced in the peripheral tissues of both genders. Type 5 of …

SHORT-CHAIN FATTY ACIDS (SCFAs), acetate, propionate, and butyrate are produced by
bacterial fermentation of dietary fiber in the colonic lumen. In the normal human large …

Epidemiological studies suggest that colonic production of butyrate and estrogen may be
involved in human susceptibility to colorectal cancer (CRC). Estrone (E1) can be produced …

Infections with oncogenic human papillomavirus (HPV) strains are recognized as the major
risk factor for developing malignant lesions in the uterine cervix. However, several findings …

Epigenome changes have been widely demonstrated to contribute to the initiation and
progression of a vast array of cancers including breast cancer. The reversible process of …

Colorectal cancer (CRC) is considered an estrogen-dependent malignancy, and intratissue
estrogen concentration can be controlled by steroid sulfatase (STS). Little is known about …