The retina is an emerging CNS target for potential noninvasive diagnosis and tracking of
Alzheimer's disease (AD). Studies have identified the pathological hallmarks of AD …

The possible interconnection between the eye and central nervous system (CNS) has been
a topic of discussion for several years just based on fact that the eye is properly considered …

Over 60 million people worldwide are diagnosed with glaucomatous optic neuropathy,
which is estimated to be responsible for 8.4 million cases of irreversible blindness globally …

Despite high metabolic activity, the retina and optic nerve head lack traditional lymphatic
drainage. We here identified an ocular glymphatic clearance route for fluid and wastes via …

Background: Open Angle Glaucoma (POAG) is the leading causes of irreversible blindness
worldwide. Elevated intraocular pressure is considered an important risk factor for …

Neurovascular pathology concurs with protein accumulation, as the brain vasculature is
important for waste clearance. Interstitial solutes, such as amyloid-β, were previously …

Traumatic brain injury (TBI) is an increasingly important issue among veterans, athletes and
the general public. Difficulties with sleep onset and maintenance are among the most …

Background Many studies have indicated that a history of depression increases the risk of
developing Alzheimer's disease (AD); however, the potential pathogenestic mechanism by …

After the introduction of the glymphatic system hypothesis, an increasing number of studies
on cerebrospinal fluid and interstitial fluid dynamics within the brain have been investigated …

The ocular glymphatic system supports bidirectional fluid transport along the optic nerve,
thereby removes metabolic wastes including amyloid-β. To better understand this biological …