[PDF][PDF] Role and regulation of RUNX2 in osteogenesis
Runt-related transcription factor 2 (RUNX2) is a transcription factor closely associated with
the osteoblast phenotype. While frequently referred to, the complexity of its regulation and its …
the osteoblast phenotype. While frequently referred to, the complexity of its regulation and its …
RUNX transcription factors: orchestrators of development
ABSTRACT RUNX transcription factors orchestrate many different aspects of biology,
including basic cellular and developmental processes, stem cell biology and tumorigenesis …
including basic cellular and developmental processes, stem cell biology and tumorigenesis …
Tyrosine phosphorylation controls Runx2‐mediated subnuclear targeting of YAP to repress transcription
Src/Yes tyrosine kinase signaling contributes to the regulation of bone homeostasis and
inhibits osteoblast activity. Here we show that the endogenous Yes‐associated protein …
inhibits osteoblast activity. Here we show that the endogenous Yes‐associated protein …
Networks and hubs for the transcriptional control of osteoblastogenesis
JB Lian, GS Stein, A Javed, AJ Van Wijnen… - Reviews in Endocrine …, 2006 - Springer
We present an overview of the concepts of tissue-specific transcriptional control
mechanisms essential for development of the bone cell phenotype. BMP2 induced …
mechanisms essential for development of the bone cell phenotype. BMP2 induced …
Regulatory controls for osteoblast growth and differentiation: role of Runx/Cbfa/AML factors
Formation of skeletal elements during embryogenesis and the dynamic remodeling of bone
in the adult involve an exquisite interplay of developmental cues, signaling proteins …
in the adult involve an exquisite interplay of developmental cues, signaling proteins …
Runx2: a master organizer of gene transcription in developing and maturing osteoblasts
TM Schroeder, ED Jensen… - Birth Defects Research …, 2005 - Wiley Online Library
Runx2 is essential for osteoblast development and proper bone formation. A member of the
Runt domain family of transcription factors, Runx2 binds specific DNA sequences to regulate …
Runt domain family of transcription factors, Runx2 binds specific DNA sequences to regulate …
Runx2 (Cbfa1, AML-3) interacts with histone deacetylase 6 and represses the p21CIP1/WAF1 promoter
JJ Westendorf, SK Zaidi, JE Cascino… - … and cellular biology, 2002 - Am Soc Microbiol
Abstract Runx2 (Cbfa1, AML-3) is multifunctional transcription factor that is essential for
osteoblast development. Runx2 binds specific DNA sequences and interacts with …
osteoblast development. Runx2 binds specific DNA sequences and interacts with …
Transcriptional programming in arteriosclerotic disease: a multifaceted function of the Runx2 (runt-related transcription factor 2)
Despite successful therapeutic strategies in the prevention and treatment of arteriosclerosis,
the cardiovascular complications remain a major clinical and societal issue worldwide …
the cardiovascular complications remain a major clinical and societal issue worldwide …
Dlx3 transcriptional regulation of osteoblast differentiation: temporal recruitment of Msx2, Dlx3, and Dlx5 homeodomain proteins to chromatin of the osteocalcin gene
MQ Hassan, A Javed, MI Morasso, J Karlin… - … and cellular biology, 2004 - Taylor & Francis
Genetic studies show that Msx2 and Dlx5 homeodomain (HD) proteins support skeletal
development, but null mutation of the closely related Dlx3 gene results in early embryonic …
development, but null mutation of the closely related Dlx3 gene results in early embryonic …
The vaccinia-related kinases phosphorylate the N′ terminus of BAF, regulating its interaction with DNA and its retention in the nucleus
The vaccinia-related kinases (VRKs) comprise a branch of the casein kinase family whose
members are characterized by homology to the vaccinia virus B1 kinase. The VRK …
members are characterized by homology to the vaccinia virus B1 kinase. The VRK …