" It is perhaps today, where a certain underevaluation-well, even disrespect-of scientific
research is growing-useful again and again to refer to the fact of how well suited the …

Type 1 diabetes mellitus results from autoimmune destruction of the insulin-secreting cells in
the pancreas. Daily treatment with exogenous insulin is required, but because of difficulties …

The use of embryonic stem cells for cell-replacement therapy in diseases like diabetes
mellitus requires methods to control the development of multipotent cells. We report that …

Recent advances in clinical protocols have improved the outcomes of pancreatic islet
transplantation (PIT), yet PIT recipients typically require pancreatic islet grafts derived from …

The molecular and cellular mechanisms responsible for cytotoxic T lymphocyte (CTL)-
induced immunopathology are not well defined. Using a model in which hepatitis B surface …

We investigated the capacity of human islets to produce monocyte chemoattractant protein-1
(MCP-1). Primary cultures of pancreatic islets expressed and secreted MCP-1, as …

Early impairment of islet function and graft loss limit the success of allogeneic islet
transplantation. Nonspecific inflammatory events occurring at the transplant site immediately …

Transplantation of islets of Langerhans represents a viable therapeutic approach for the
treatment of type 1 diabetes. Unfortunately, transplanted islets are susceptible to allogeneic …

Encapsulation of cells and tissue offers a rational approach for attenuating deleterious host
responses toward transplanted cells, but a need exists to develop cell encapsulation …

The successful demonstration that insulin-produc-ing-cells can be isolated (in the form of
cell clusters called islets containing and other endocrine and nonendocrine cells) from a …