The possible link between hIAPP accumulation and β-cell death in diabetic patients has
inspired numerous studies focusing on amyloid structures and aggregation pathways of this …

Islet amyloid polypeptide (IAPP, or amylin) is one of the major secretory products of β-cells of
the pancreatic islets of Langerhans. It is a regulatory peptide with putative function both …

Human islet amyloid polypeptide (hIAPP) functions as a glucose-regulating hormone but
deposits as amyloid fibrils in more than 90% of patients with type II diabetes (T2D). Here we …

The molecular mechanisms by which different proteins assemble into highly ordered fibrillar
deposits and cause disease remain topics of debate. Human amylin (also known as islet …

Human Islet Amyloid Polypeptide (hIAPP) is a highly amyloidogenic protein found in islet
cells of patients with type II diabetes. Because hIAPP is highly toxic to β-cells under certain …

Pancreatic islet amyloid is a characteristic feature of type 2 diabetes. The major protein
component of islet amyloid is the polypeptide hormone known as islet amyloid polypeptide …

Polyglutamine (polyQ) sequences of unknown normal function are present in a significant
number of proteins, and their repeat expansion is associated with a number of genetic …

Amyloid formation has been implicated in the pathology of over 20 human diseases, but the
rational design of amyloid inhibitors is hampered by a lack of structural information about …

Lewy bodies (LBs) are intraneuronal inclusions consisting primarily of fibrillized human α-
synuclein (hα-Syn) protein, which represent the major pathological hallmark of Parkinson's …

Islet amyloid polypeptide (IAPP, amylin) is responsible for amyloid formation in type 2
diabetes and in transplanted islets. The flavanol (−)-epigallocatechin-3-gallate [EGCG;(2 R …