Biological materials are self-assembled with near-atomic precision in living cells, whereas
synthetic 3D structures generally lack such precision and controllability. Recently, DNA …

Dynamic DNA nanotechnology, a subfield of DNA nanotechnology, is concerned with the
study and application of nucleic acid strand-displacement reactions. Strand-displacement …

DNA has become one of the most extensively used molecular building blocks for
engineering self-assembling materials. DNA origami is a technique that uses hundreds of …

The predictable nature of DNA interactions enables the programmable assembly of highly
advanced 2D and 3D DNA structures of nanoscale dimensions. The access to ever larger …

INTRODUCTION Since the 1980s, the design and synthesis of molecular machines has
been identified as a grand challenge for molecular engineering. Robots are an important …

DNA-encoded chemical library technologies are increasingly being adopted in drug
discovery for hit and lead generation. DNA-encoded chemistry enables the exploration of …

Cells use spatial constraints to control and accelerate the flow of information in enzyme
cascades and signalling networks. Synthetic silicon-based circuitry similarly relies on spatial …

Designer DNA nanodevices have attracted extensive interest for detection of specific targets
in living cells. However, it still remains a great challenge to construct DNA sensing devices …

With the ultimate aim to construct a living cell, bottom-up synthetic biology strives to
reconstitute cellular phenomena in vitro–disentangled from the complex environment of a …

INTRODUCTION Embedded controllers enable complex functionality in man-made
mechanical and electronic devices. Similarly, intricate regulatory networks within living …