Toward kingdom-wide analyses of gene expression
Gene expression data for Archaeplastida are accumulating exponentially, with more than
300 000 RNA-sequencing (RNA-seq) experiments available for hundreds of species. The …
300 000 RNA-sequencing (RNA-seq) experiments available for hundreds of species. The …
Modeling and analysis of RNA‐seq data: a review from a statistical perspective
Background Since the invention of next‐generation RNA sequencing (RNA‐seq)
technologies, they have become a powerful tool to study the presence and quantity of RNA …
technologies, they have become a powerful tool to study the presence and quantity of RNA …
Directed differentiation of human iPSCs to functional ovarian granulosa-like cells via transcription factor overexpression
An in vitro model of human ovarian follicles would greatly benefit the study of female
reproduction. Ovarian development requires the combination of germ cells and several …
reproduction. Ovarian development requires the combination of germ cells and several …
Human microglia maturation is underpinned by specific gene regulatory networks
Microglia phenotypes are highly regulated by the brain environment, but the transcriptional
networks that specify the maturation of human microglia are poorly understood. Here, we …
networks that specify the maturation of human microglia are poorly understood. Here, we …
Liver cancer heterogeneity modeled by in situ genome editing of hepatocytes
M Tang, Y Zhao, J Zhao, S Wei, M Liu, N Zheng… - Science …, 2022 - science.org
Mechanistic study and precision treatment of primary liver cancer (PLC) are hindered by
marked heterogeneity, which is challenging to recapitulate in any given liver cancer mouse …
marked heterogeneity, which is challenging to recapitulate in any given liver cancer mouse …
Neyman-Pearson classification algorithms and NP receiver operating characteristics
In many binary classification applications, such as disease diagnosis and spam detection,
practitioners commonly face the need to limit type I error (that is, the conditional probability of …
practitioners commonly face the need to limit type I error (that is, the conditional probability of …
A longer time to relapse is associated with a larger increase in differences between paired primary and recurrent IDH wild-type glioblastomas at both the …
WM Ho, CY Chen, TW Chiang, TJ Chuang - Acta Neuropathologica …, 2024 - Springer
Glioblastoma (GBM) is the most common malignant brain tumor in adults, which remains
incurable and often recurs rapidly after initial therapy. While large efforts have been …
incurable and often recurs rapidly after initial therapy. While large efforts have been …
Pathway‐Based Similarity Measurement to Quantify Transcriptomics Similarity Between Human Tissues and Preclinical Models
Accurate clinical translation of preclinical research remains challenging, primarily due to
species‐specific differences and disease and patient heterogeneity. An important recent …
species‐specific differences and disease and patient heterogeneity. An important recent …
HCC Model Induced by P53 and Pten Knockout in HBV‐Transgenic Mice Mirrors Human HCC at the Transcriptome Level
Z Chen, J Yang, Y Song, X Chen… - Journal of Medical …, 2024 - Wiley Online Library
With a multitude of HCC mouse models available, choosing the one that most closely
resembles human HCC can be challenging. This study addresses this gap by conducting a …
resembles human HCC can be challenging. This study addresses this gap by conducting a …
An information-theoretic approach for measuring the distance of organ tissue samples using their transcriptomic signatures
DV Manatakis, A VanDevender, ES Manolakos - Bioinformatics, 2020 - academic.oup.com
Motivation Recapitulating aspects of human organ functions using in vitro (eg plates,
transwells, etc.), in vivo (eg mouse, rat, etc.), or ex vivo (eg organ chips, 3D systems, etc.) …
transwells, etc.), in vivo (eg mouse, rat, etc.), or ex vivo (eg organ chips, 3D systems, etc.) …