A new software system called PHENIX (Python-based Hierarchical ENvironment for
Integrated Xtallography) is being developed for the automation of crystallographic structure …

Structural genomics seeks to expand rapidly the number of protein structures in order to
extract the maximum amount of information from genomic sequence databases. The advent …

Estimates of the quality of experimental maps are important in many stages of structure
determination of macromolecules. Map quality is defined here as the correlation between a …

Obtaining an electron-density map from X-ray diffraction data can be difficult and time-
consuming even after the data have been collected, largely because MIR and MAD structure …

FhuA, the receptor for ferrichrome-iron in Escherichia coli, is a member of a family of integral
outer membrane proteins, which, together with the energy-transducing protein TonB …

FhuA protein facilitates ligand-gated transport of ferrichrome-bound iron across Escherichia
coli outer membranes. X-ray analysis at 2.7 Å resolution reveals two distinct conformations …

Because of its stringent sequence specificity, the 3C-type protease from tobacco etch virus
(TEV) is frequently used to remove affinity tags from recombinant proteins. It is unclear …

Publisher Summary The software packages SOLVE and RESOLVE comprise a suite for an
automated structure solution using multiple isomorphous replacement (MIR) …

The structure of a Nova protein K homology (KH) domain recognizing single-stranded RNA
has been determined at 2.4 Å resolution. Mammalian Nova antigens (1 and 2) constitute an …

Human p32 (also known as SF2-associated p32, p32/TAP, and gC1qR) is a conserved
eukaryotic protein that localizes predominantly in the mitochondrial matrix. It is thought to be …