Heat shock proteins are essential molecular chaperones that play crucial roles in stabilizing
protein structures, facilitating the repair or degradation of damaged proteins, and …

Recently, there is a rise in studies that recognize the importance of targeting ubiquitin and
related molecular machinery in various therapeutic contexts. Here we briefly discuss the …

N-Myc is a key driver of neuroblastoma and neuroendocrine prostate cancer (NEPC). One
potential way to circumvent the challenge of undruggable N-Myc is to target the protein …

Abstract Treatment-induced neuroendocrine prostate cancer (t-NEPC) often arises from
adenocarcinoma via lineage plasticity in response to androgen receptor signaling inhibitors …

Nobiletin (NBT) is a unique flavonoid mainly found in citrus fruits and has been reported to
inhibit colon carcinogenesis in multiple rodent models. However, the direct molecular targets …

Over the last few decades, the incidence of urogenital cancers has exhibited diverse trends
influenced by screening programs and geographical variations. Among women, there has …

Paclitaxel (PTX) is a first-line drug for ovarian cancer (OC) treatment. However, the
regulatory mechanism of STUB1 on ferroptosis and PTX resistance in OC remains unclear …

Background The Androgen Receptor (AR) pathway is crucial in driving the progression of
prostate cancer (PCa) to an advanced state. Despite the introduction of second-generation …

Uncontrollable cancer cell growth is characterized by the maintenance of cellular
homeostasis through the continuous accumulation of misfolded proteins and damaged …

Abstract Treatment-induced neuroendocrine prostate cancer (t-NEPC) often arises from
adenocarcinoma via lineage plasticity in response to androgen receptor signaling inhibitors …