Pantothenate and CoA biosynthesis in Apicomplexa and their promise as antiparasitic drug targets

LE de Vries, M Lunghi, A Krishnan, TWA Kooij… - PLoS …, 2021 - journals.plos.org
The Apicomplexa phylum comprises thousands of distinct intracellular parasite species,
including coccidians, haemosporidians, piroplasms, and cryptosporidia. These parasites are …

Recent advances in targeting coenzyme A biosynthesis and utilization for antimicrobial drug development

WJA Moolman, M de Villiers… - Biochemical Society …, 2014 - portlandpress.com
The biosynthesis and utilization of CoA (coenzyme A), the ubiquitous and essential acyl
carrier in all organisms, have long been regarded as excellent targets for the development of …

Antimalarial pantothenamide metabolites target acetyl–coenzyme A biosynthesis in Plasmodium falciparum

J Schalkwijk, EL Allman, PAM Jansen… - Science translational …, 2019 - science.org
Malaria eradication is critically dependent on new therapeutics that target resistant
Plasmodium parasites and block transmission of the disease. Here, we report that …

Preclinical characterization and target validation of the antimalarial pantothenamide MMV693183

LE de Vries, PAM Jansen, C Barcelo, J Munro… - Nature …, 2022 - nature.com
Drug resistance and a dire lack of transmission-blocking antimalarials hamper malaria
elimination. Here, we present the pantothenamide MMV693183 as a first-in-class acetyl …

Multi-omics analysis of gut microbiota and metabolites reveals contrasting profiles in domestic pigs and wild boars across urban environments

J Ding, X Cui, X Wang, F Zhai, L Wang… - Frontiers in …, 2024 - frontiersin.org
The gut microbiota plays a crucial role in host health and metabolism. This study explores
the differences in gut microbiota and metabolites between domestic pigs (DP) and wild …

A screen of drug-like molecules identifies chemically diverse electron transport chain inhibitors in apicomplexan parasites

JA Hayward, FV Makota, D Cihalova… - PLoS …, 2023 - journals.plos.org
Apicomplexans are widespread parasites of humans and other animals, and include the
causative agents of malaria (Plasmodium species) and toxoplasmosis (Toxoplasma gondii) …

Water recycling efficacies of extremely hygroscopic, antifouling hydrogels

A Kabir, MJ Dunlop, B Acharya, R Bissessur… - RSC advances, 2018 - pubs.rsc.org
Water harvesting, reusable, and antifouling hydrogels have found various applications in the
fields of nanotechnology, biomedicine, food production and agriculture. These water …

Triazole substitution of a labile amide bond stabilizes pantothenamides and improves their antiplasmodial potency

VM Howieson, E Tran, A Hoegl, HL Fam… - Antimicrobial Agents …, 2016 - Am Soc Microbiol
The biosynthesis of coenzyme A (CoA) from pantothenate and the utilization of CoA in
essential biochemical pathways represent promising antimalarial drug targets …

A pantetheinase-resistant pantothenamide with potent, on-target, and selective antiplasmodial activity

CJ Macuamule, ET Tjhin, CE Jana… - Antimicrobial agents …, 2015 - Am Soc Microbiol
Pantothenamides inhibit blood-stage Plasmodium falciparum with potencies (50% inhibitory
concentration [IC50],∼ 20 nM) similar to that of chloroquine. They target processes …

Toward a Stable and Potent Coenzyme A-Targeting Antiplasmodial Agent: Structure–Activity Relationship Studies of N-Phenethyl-α-methyl-pantothenamide

C Spry, L Barnard, M Kok, AK Powell… - ACS Infectious …, 2020 - ACS Publications
Pantothenamides (PanAms) are potent antiplasmodials with low human toxicity currently
being investigated as antimalarials with a novel mode of action. These structural analogues …