Melatonin is a ubiquitous molecule present in almost every live being from bacteria to
humans. In vertebrates, besides being produced in peripheral tissues and acting as an …

Migraine can be regarded as a conserved, adaptive response that occurs in genetically
predisposed individuals with a mismatch between the brain's energy reserve and workload …

Chronic migraine is a disabling neurological disorder that imposes a considerable burden
on individual and socioeconomic outcomes. Chronic migraine is defined as headaches …

Background The three primary headaches, tension-type headache, migraine and cluster
headache, occur in both genders, but all seem to have a sex-specific prevalence. These …

The brain and body respond to potential and actual stressful events by activating hormonal
and neural mediators and modifying behaviors to adapt. Such responses help maintain …

Despite that it is commonly accepted that migraine is a disorder of the nervous system with a
prominent genetic basis, it is comorbid with a plethora of medical conditions. Several studies …

Background Migraine is a highly prevalent and disabling neurological disorder which is
commonly linked with a broad range of psychiatric comorbidities, especially among subjects …

Recent theories have suggested that chronic pain could be partly maintained by
maladaptive physiological responses of the organism facing a recurrent stressor. The …

Background.—Migraine sufferers experience premonitory symptoms which suggest that
primary hypothalamic dysfunction is a likely trigger of the attacks. Neuroendocrine and …

Migraine is a severe neurovascular disorder of which the pathophysiology is not yet fully
understood. Besides the role of inflammatory mediators that interact with the …