Abstract Ten-Eleven Translocation-2 (TET2) inactivation through loss-of-function mutation,
deletion and IDH1/2 (Isocitrate Dehydrogenase 1 and 2) gene mutation is a common event …

Abstract The epigenetic mark 5-hydroxymethylcytosine (5hmC) has gained interest since
2009, when it was discovered that Ten-Eleven-Translocation (TET) proteins catalyze the …

Abstract TET (ten-eleven-translocation) proteins are Fe (ii)-and α-ketoglutarate-dependent
dioxygenases,, that modify the methylation status of DNA by successively oxidizing 5 …

The myelodysplastic syndromes (MDSs) are a heterogeneous group of clonal
haematological diseases characterized by ineffective haematopoiesis and predisposition to …

Cytochrome c oxidase (COX) is the terminal enzyme of the electron transport chain, made
up of 13 subunits encoded by both mitochondrial and nuclear DNA. Subunit 4 (COX4), a key …

TLR7/9 signals are capable of mounting massive interferon (IFN) response in plasmacytoid
dendritic cells (pDCs) immediately after viral infection, yet the involvement of epigenetic …

The Wilms' tumor suppressor 1 (WT1) gene encodes a DNA-and RNA-binding protein that
plays an essential role in nephron progenitor differentiation during renal development. To …

The positive roles of the Wnt/β-catenin pathway in osteoblast differentiation and bone
mineral density (BMD) maintenance have been clearly demonstrated in both animal …

CXXC5 is a member of the CXXC‐type zinc‐finger protein family. Proteins in this family play
a pivotal role in epigenetic regulation by binding to unmethylated CpG islands in gene …

Tet proteins are emerging as major epigenetic modulators of cell fate and plasticity.
However, little is known about how Tet proteins are targeted to selected genomic loci in …